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Related Concept Videos

Sites for measuring blood pressure01:21

Sites for measuring blood pressure

Blood pressure measurement is a fundamental clinical procedure, providing crucial data for assessing cardiovascular health. Among the various sites for this measurement, the brachial and popliteal arteries are predominantly utilized due to their accessibility and the reliability of their readings. This lesson delves into the anatomical significance, methodology, and considerations of measuring blood pressure at these locations.
The Brachial Artery: Primary Site for Blood Pressure Measurement
Equipments Used To Measure Blood Pressure01:30

Equipments Used To Measure Blood Pressure

Direct Method
This invasive approach involves cannulating a peripheral artery. During each cardiac contraction, pressure generates mechanical motion within the catheter, transmitted through rigid, fluid-filled tubing to a transducer. This transducer converts mechanical motion into electrical signals displayed as waveforms on a monitor. An automatic flushing system prevents blood backflow. Due to the potential risk of unexpected arterial blood loss, this method is primarily used in intensive...
Assessment of blood pressure in brachial artery(two-step method)01:23

Assessment of blood pressure in brachial artery(two-step method)

Measuring blood pressure is a fundamental skill in healthcare that aids in diagnosing and monitoring hypertension and other cardiovascular conditions. An aneroid sphygmomanometer, commonly used in clinical settings, offers a manual and precise method for blood pressure measurement. The technique for using this instrument involves specific steps that must be carefully executed to ensure accuracy. The following detailed description outlines a two-step technique for assessing blood pressure using...
Measurement of Blood Pressure01:17

Measurement of Blood Pressure

Assessing blood pressure is a standard procedure executed in virtually all medical environments. The method utilized today was established over a hundred years ago by an innovative Russian doctor, Dr. Nikolai Korotkoff. The soft ticking noise, known as Korotkoff sounds, heard while taking blood pressure readings results from turbulent blood flow within the vessels. The apparatus required for this procedure includes a sphygmomanometer, a blood pressure cuff attached to a gauge, and a stethoscope.
Cardiac Catheterization II: Right Heart Catheterization01:21

Cardiac Catheterization II: Right Heart Catheterization

Right Heart Catheterization: An OverviewRight heart catheterization is an invasive diagnostic procedure that measures right-sided cardiac and pulmonary artery pressures, calculates cardiac output, and identifies intracardiac shunts. It provides detailed hemodynamic data essential for diagnosing and managing various cardiovascular conditions, such as pulmonary hypertension.Access SitesCommon access sites for right heart catheterization include the internal jugular vein in the neck region, the...
Mitral Regurgitation I: Introduction01:20

Mitral Regurgitation I: Introduction

Mitral regurgitation is characterized by the backward circulation of blood from the left ventricle to the left atrium during systole, a phase of the cardiac cycle when the heart contracts and pumps blood out of the chambers. This abnormal flow occurs primarily due to the dysfunction of the mitral valve or its supporting structures, which include the mitral leaflets, chordae tendineae, annulus, and papillary muscles.Etiology and Mechanisms:Primary Mitral Regurgitation: This type arises from...

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Related Experiment Video

Updated: Jun 22, 2026

Assessment of Right Ventricular Structure and Function in Mouse Model of Pulmonary Artery Constriction by Transthoracic Echocardiography
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An Unsupervised Approach to Derive Right Ventricular Pressure-Volume Loop Phenotypes in Pulmonary Hypertension.

Nikita Sivakumar1,2, Cindy Zhang1,2, Connie Chang-Chien1

  • 1Institute for Computational Medicine Johns Hopkins University Baltimore Maryland USA.

Pulmonary Circulation
|February 24, 2025
PubMed
Summary

Right ventricle (RV) dysfunction impacts pulmonary hypertension (PH) worsening. Researchers mapped standard measurements to RV function phenotypes, enabling prediction of patient groups using accessible data like exercise mean pulmonary arterial pressure.

Keywords:
cardiac resonance imagingright heart catheterizationright ventricular‐pulmonary arterial couplingunsupervised clustering

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Area of Science:

  • Cardiology
  • Pulmonary Hypertension Research
  • Cardiac Physiology

Background:

  • Right ventricle (RV) dysfunction is a key driver of clinical deterioration in pulmonary hypertension (PH).
  • Current PH risk assessment inadequately integrates RV function information.
  • Multi-beat pressure-volume (PV) loops are the gold standard for assessing RV function and ventriculo-arterial coupling but are not clinically feasible.

Purpose of the Study:

  • To correlate standard, clinically available measurements with PV loop-derived RV functional phenotypes.
  • To develop a predictive model for RV functional phenotypes using accessible clinical data.
  • To investigate the utility of exercise hemodynamics in characterizing RV function.

Main Methods:

  • One hundred and one patients with suspected PH underwent right heart catheterization (RHC) with exercise, multi-beat PV loop measurement, and cardiac magnetic resonance imaging (CMR).
  • Unsupervised k-means clustering was applied to 10 PV loop metrics to identify distinct RV functional phenotypes.
  • A random forest classifier was trained using RHC and CMR data to predict these PV loop phenotypes.

Main Results:

  • Three distinct patient groups with unique RV functional phenotypes and varying times to clinical worsening were identified.
  • The random forest classifier achieved high discrimination (AUC = 0.93) in predicting PV loop phenotypes.
  • Exercise mean pulmonary arterial pressure (mPAP) emerged as the most informative variable for predicting RV functional phenotypes.

Conclusions:

  • Clinically meaningful RV functional phenotypes, identifiable via PV loops, can be predicted using standard hemodynamic and RV-centric measurements.
  • Accessible clinical data, particularly exercise mPAP, can effectively predict these distinct RV functional phenotypes.
  • Exercise mPAP may serve as a valuable surrogate for understanding RV pressure-volume relationships in PH assessment.