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A Neurological Manifestation of Anaplasmosis: A Case Report
Siddartha Guru1, Marvi Mahar2, Navami Guru3
1Infectious Diseases, Penn State Health Milton S. Hershey Medical Center, Hershey, USA.
Abstract:
Human granulocytic anaplasmosis (HGA) is a tick-borne infection caused by a small intracellular gram-negative bacteria called Anaplasma phagocytophilum. It is a multisystemic disease, but neurological manifestations are rare. We report a rare neurological manifestation of stroke in a 65-year-old woman who presented initially with abdominal pain, nausea, vomiting, and dizziness. She developed worsening renal function and encephalopathy requiring hemodialysis and intubation for airway protection. Brain imaging showed acute infarcts. Morulae were seen on the peripheral smear. The diagnosis was confirmed with a positive Anaplasma PCR. Her mentation improved after 48 hours on doxycycline.
Insights
Human granulocytic anaplasmosis (HGA), a rare tick-borne illness, can cause neurological issues like stroke. Early diagnosis and doxycycline treatment led to a patient's recovery.
Area of Science:
- Infectious Diseases
- Neurology
- Microbiology
Background:
- Human granulocytic anaplasmosis (HGA) is a tick-borne disease caused by *Anaplasma phagocytophilum*.
- While typically multisystemic, neurological manifestations of HGA are uncommon.
- This case highlights a rare presentation of HGA with severe neurological complications.
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