Achieving a Good Response in Myxofibrosarcoma With Uncontrollable Bleeding Using an Enzyme-Targeting...

Area of Science:

• Oncology
• Radiation Oncology
• Surgical Oncology

Background:

• Myxofibrosarcoma is a common soft tissue sarcoma of the extremity.
• Post-operative radiation therapy is a standard treatment modality.
• Surgical intervention is often the primary treatment for soft tissue sarcomas.

Observation:

• A 78-year-old male presented with a large, recurrent myxofibrosarcoma on his forearm.
• The patient refused surgical treatment due to tumor size and location.
• The tumor exhibited repeated recurrences and bleeding over seven years.

Findings:

• Kochi oxydol radiation therapy for unresectable carcinomas (KORTUC) involves topical application (KORTUC I) and injection (KORTUC II) of hydrogen peroxide solution.
• The patient was treated with both KORTUC I and KORTUC II for the unresectable myxofibrosarcoma.
• A favorable response to KORTUC treatment was observed, managing tumor recurrence and bleeding.

Implications:

• This case suggests KORTUC may be an effective treatment option for myxofibrosarcoma, particularly in patients unsuitable for surgery.
• Limited reports exist on KORTUC for sarcomas, indicating a need for further research.
• Future studies should explore KORTUC's efficacy in managing unresectable or recurrent soft tissue sarcomas.