Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Increased Body Temperature01:25

Increased Body Temperature

636
A body temperature above  38°C  (100.4 °F) is known as fever or pyrexia, and a person with fever is termed 'febrile.' Typically, the hypothalamus, a part of the brain that acts as the body's thermostat, regulates body temperature through a thermoregulatory setpoint. It receives signals from cold and warm thermal receptors throughout the body and adjusts the body's temperature accordingly. Fever occurs when this hypothalamic setpoint is altered, usually in...
636
GTPases and their Regulation02:14

GTPases and their Regulation

2.2K
2.2K
Skin Diseases and Disorders01:23

Skin Diseases and Disorders

2.8K
Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
2.8K
Taste Buds and Receptors01:20

Taste Buds and Receptors

1.8K
Gustation, or the sense of taste, is intrinsically linked to the anatomical structures located on the tongue. This organ's surface, along with the entirety of the oral cavity, is adorned with stratified squamous epithelium. Evident on the tongue are elevated structures known as papillae (singular = papilla), which house the mechanisms for the transduction of gustatory stimuli. Four distinct types of papillae exist, each identified by their unique morphological attributes: the circumvallate,...
1.8K
Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

12.3K
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
12.3K
Proteoglycans01:05

Proteoglycans

3.9K
Glycans, a class of complex heterogeneous molecules, can be covalently attached to proteins to form glycosylated proteins that regulate various physiological and pathological processes. Glycosylated proteins or glycoproteins comprise N-linked and O-linked oligosaccharides. O-glycosylation is the most common type of protein glycosylation. Here, glycans attach to the oxygen atom of the hydroxyl groups of Serine or Threonine residues. O-linked glycosylation occurs later in protein processing,...
3.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Stress Sensing Based on Upconversion Piezo-Luminescence Effect.

Inorganic chemistry·2026
Same author

Age-Dependent Differences in Canakinumab Safety: A Comprehensive Pharmacovigilance Analysis Using the FAERS Database.

Pharmacology research & perspectives·2026
Same author

Intravascular Large B-Cell Lymphoma Presenting With Urinary and Fecal Incontinence: A Case Report.

Clinical case reports·2026
Same author

Evolving trends in medical trainee wellbeing research from 2014 to 2023: A bibliometric analysis.

Medicine·2025
Same author

How AI Is Transforming Medical Education: Bibliometric Analysis.

JMIR medical education·2025
Same author

You Need Glimpse Before Segmentation: Stochastic Detector-Actor-Critic for Medical Image Segmentation.

IEEE journal of biomedical and health informatics·2025
Same journal

Metastatic Unfunctional Pancreatic Neuroendocrine Tumor in Lynch Syndrome.

Clinical case reports·2026
Same journal

Pediatric Cholesteatoma Presenting as Persistent Otorrhea: A Case of Delayed Diagnosis Across Multiple ENT Specialists.

Clinical case reports·2026
Same journal

Challenges in Diagnosis and Management of Crohn's Disease in Bangladesh With Long Term Follow-Up.

Clinical case reports·2026
Same journal

Systemic Treatment of Orthodontic Elastic Band-Induced Periodontitis: A Case Report.

Clinical case reports·2026
Same journal

Clear Cell Sarcoma of the Kidney Case Reports Should Connect Renal-Origin Imaging With Staging, Treatment Rationale, and Follow-Up.

Clinical case reports·2026
Same journal

When a Bulbar Ulcer Hides a Darker Reality: The Unusual Diagnosis of a Portal Cavernoma in a 69-Year-Old Adult.

Clinical case reports·2026
See all related articles

Related Experiment Video

Updated: May 26, 2025

Obtaining Highly Purified Toxoplasma gondii Oocysts by a Discontinuous Cesium Chloride Gradient
11:17

Obtaining Highly Purified Toxoplasma gondii Oocysts by a Discontinuous Cesium Chloride Gradient

Published on: November 3, 2009

13.6K

Tophaceous Gout.

Yunxin Liu1, Yang Jiao1

  • 1Department of General Practice (General Internal Medicine) Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College Beijing China.

Clinical Case Reports
|February 24, 2025
PubMed
Summary
This summary is machine-generated.

Chronic hyperuricemia can cause severe gout, leading to joint damage and bone erosion. Early detection of gouty arthritis, characterized by specific X-ray findings, is crucial for preventing long-term complications.

Keywords:
arthritisgouthyperuricemiaoverhanging edgestophus

More Related Videos

Targeting Drugs to Larval Zebrafish Macrophages by Injecting Drug-Loaded Liposomes
11:31

Targeting Drugs to Larval Zebrafish Macrophages by Injecting Drug-Loaded Liposomes

Published on: February 18, 2020

7.6K
An Immunohistopathologic Study to Profile the Folate Receptor Beta Macrophage and Vascular Immune Microenvironment in Giant Cell Arteritis
06:35

An Immunohistopathologic Study to Profile the Folate Receptor Beta Macrophage and Vascular Immune Microenvironment in Giant Cell Arteritis

Published on: February 8, 2019

7.1K

Related Experiment Videos

Last Updated: May 26, 2025

Obtaining Highly Purified Toxoplasma gondii Oocysts by a Discontinuous Cesium Chloride Gradient
11:17

Obtaining Highly Purified Toxoplasma gondii Oocysts by a Discontinuous Cesium Chloride Gradient

Published on: November 3, 2009

13.6K
Targeting Drugs to Larval Zebrafish Macrophages by Injecting Drug-Loaded Liposomes
11:31

Targeting Drugs to Larval Zebrafish Macrophages by Injecting Drug-Loaded Liposomes

Published on: February 18, 2020

7.6K
An Immunohistopathologic Study to Profile the Folate Receptor Beta Macrophage and Vascular Immune Microenvironment in Giant Cell Arteritis
06:35

An Immunohistopathologic Study to Profile the Folate Receptor Beta Macrophage and Vascular Immune Microenvironment in Giant Cell Arteritis

Published on: February 8, 2019

7.1K

Area of Science:

  • Rheumatology
  • Orthopedics
  • Radiology

Background:

  • Chronic untreated hyperuricemia is a precursor to gout.
  • Recurrent arthritis in gout can result in significant joint damage and bone erosion.
  • Tophaceous gout, characterized by urate crystal deposits, can manifest even in younger individuals with sustained hyperuricemia.

Purpose of the Study:

  • To highlight the link between chronic hyperuricemia and the development of polyarticular tophaceous gout.
  • To emphasize the diagnostic significance of "overhanging edges" on X-ray as a specific indicator of gouty bone erosion.
  • To discuss the potential for tophaceous gout to affect individuals of various age groups.

Main Methods:

  • Review of clinical presentations of chronic hyperuricemia and gout.
  • Analysis of radiographic features associated with gouty arthritis.
  • Correlation of hyperuricemia duration with the incidence of tophaceous gout and joint damage.

Main Results:

  • Chronic hyperuricemia untreated can progress to polyarticular tophaceous gout.
  • Radiographic "overhanging edges" are a highly specific sign of bony erosions caused by gout.
  • Tophaceous gout is observed in younger individuals with prolonged hyperuricemia, not exclusively in older adults.

Conclusions:

  • Untreated hyperuricemia poses a significant risk for developing severe gout with bone erosion and joint damage.
  • "Overhanging edges" on X-ray are a critical diagnostic marker for gout-induced bony lesions.
  • Proactive management of hyperuricemia is essential to prevent the progression to tophaceous gout and its associated joint destruction, regardless of patient age.