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Updated: May 16, 2026

Intramuscular Injections Along the Motor End Plates: A Minimally Invasive Approach to Shuttle Tracers Directly into Motor Neurons
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Intramuscular Injection of rAAV2-retro for Low Motor Neuron Transduction: Evaluating Five Promoters

Xueqi Gong1,2, Haitong Gao1,2, Wenyuan Wang3,4

  • 1Laboratory Animal Center, Fudan University, Shanghai 200032, China.

International Journal of Medical Sciences
|February 24, 2025
PubMed
Summary

Recombinant adeno-associated viral vectors (rAAVs) efficiently deliver genes to lower motor neurons (LMNs) in the brainstem and spinal cord. The CAG and hCMV promoters showed the highest gene expression without causing toxicity, optimizing gene delivery for motor neuron diseases.

Keywords:
gene therapylight-sheetmotor neuronpromoterrAAV2-retro

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