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Related Concept Videos

Hand hygiene01:23

Hand hygiene

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Asepsis is the practice of preventing or breaking the chain of infection. The nurse employs aseptic techniques to prevent the spread of microorganisms and reduce the risk of diseases. Hand hygiene is the cornerstone of aseptic techniques and is classified into medical and surgical asepsis. Medical asepsis includes hand hygiene and the use of gloves. Surgical asepsis, or the sterile technique, refers to practices that render and keep objects and areas free of microorganisms.
Hand washing...
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Local Anesthetics: Clinical Application as Intravenous Regional Anesthesia01:16

Local Anesthetics: Clinical Application as Intravenous Regional Anesthesia

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Intravenous regional anesthesia or the Bier block technique is used to anesthetize a specific limb or extremity. It uses exsanguinated or blood-drained vessels to transport local anesthetics or LAs to the peripheral nerve trunks. Lidocaine without vasoconstrictors like epinephrine is most commonly used for this technique. Other drugs used are prilocaine, ropivacaine, and chloroprocaine. Bupivacaine is not recommended for this technique due to its high cardiac toxicity.
One of the advantages of...
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Drug Delivery: Parenteral Route01:29

Drug Delivery: Parenteral Route

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The parenteral route is a critical method of drug administration. It delivers compounds directly into the systemic circulation and bypasses the gastrointestinal tract. This approach is particularly advantageous for drugs that exhibit poor absorption or instability when administered orally.
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...
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Local Anesthetics: Common Agents and Their Applications01:23

Local Anesthetics: Common Agents and Their Applications

392
Local anesthetics (LAs) are commonly used for various applications in medical and dental procedures. Some of the common agents used are cocaine, lidocaine, and bupivacaine.
Cocaine is an ester of benzoic acid and methylecgogine. It is used to anesthetize and vasoconstrict locally. Currently, it is used primarily for topical applications. It is beneficial for surgeries on the upper respiratory tract, providing anesthesia and shrinking the mucosa. Cocaine in the form of cocaine hydrochloride is...
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Drug Delivery: Miscellaneous Routes01:22

Drug Delivery: Miscellaneous Routes

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Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection,  and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
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Updated: May 26, 2025

An Injectable and Drug-loaded Supramolecular Hydrogel for Local Catheter Injection into the Pig Heart
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An Injectable and Drug-loaded Supramolecular Hydrogel for Local Catheter Injection into the Pig Heart

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Injectable Hydrogel as Intracanal Medication for Root Canal Disinfection.

M Cao1, D Wu1, H Tu1

  • 1State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Department of Endodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, China.

Journal of Dental Research
|February 24, 2025
PubMed
Summary
This summary is machine-generated.

A novel injectable hydrogel, mTCP, loaded with modified triple antibiotic drugs (mTAD), offers superior root canal disinfection. This endodontic therapy agent promotes healing and root development with excellent operability and antibacterial efficacy.

Keywords:
antibacterial agentsapexificationdental disinfectantsdental pulpinfection controlregeneration

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Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications
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Area of Science:

  • Biomaterials Science
  • Endodontics
  • Regenerative Dentistry

Background:

  • Root canal disinfection is challenging due to complex anatomy and limitations of current medicaments.
  • Existing intracanal medicaments have poor permeability and suboptimal antibacterial performance.
  • A need exists for an intracanal medicament with enhanced operability and potent antibacterial properties.

Purpose of the Study:

  • To design and evaluate an injectable hydrogel, mTCP, loaded with modified triple antibiotic drugs (mTAD) for endodontic treatment.
  • To assess the characteristics, antibacterial efficacy, biocompatibility, and regenerative potential of mTCP.
  • To investigate the in vivo effects of mTCP on root canal disinfection and root development in a canine model.

Main Methods:

  • An injectable hydrogel (mTCP) was synthesized using carboxymethyl chitosan (CMCS) and polyethylene glycol aldehyde (OHC-PEG-CHO), loaded with modified triple antibiotic drugs (mTAD).
  • In vitro assessments included hydrogel characterization, antibacterial efficacy, and effects on stem cells from the apical papilla (SCAPs).
  • In vivo studies utilized a periapical inflammation model in Beagle dogs to evaluate root canal disinfection and root development.

Main Results:

  • mTCP demonstrated excellent operability, fluidity, and ease of removal from the root canal.
  • The hydrogel exhibited outstanding in vitro and in vivo antibacterial efficacy due to enhanced permeability and sustained mTAD release.
  • mTCP promoted odonto-/osteogenic differentiation of SCAPs and facilitated root elongation, dentinal wall thickening, and apical closure in vivo.

Conclusions:

  • mTCP hydrogel shows significant potential for effective root canal disinfection in endodontic therapy.
  • The material enhances root development and promotes periapical tissue healing.
  • mTCP represents a promising advancement for challenging endodontic cases requiring robust disinfection and regeneration.