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A structured, home-based exercise programme in kidney transplant recipients (ECSERT): A randomised controlled
Roseanne E Billany1, Jamie H Macdonald2, Stephanie Burns3
1Department of Cardiovascular Sciences, University of Leicester, Leicester, United Kingdom.
Plos One
|February 24, 2025
Summary
A home-based exercise program is feasible for kidney transplant recipients, exceeding recruitment and adherence targets. This study supports developing exercise interventions to improve health in this population.
Area of Science:
- Nephrology
- Exercise Physiology
- Cardiovascular Health
Background:
- Kidney transplant recipients (KTR) face high morbidity and mortality from cardiometabolic diseases.
- Physical inactivity and poor fitness are prevalent risk factors in KTR.
- Limited evidence exists on exercise interventions for KTR.
Purpose of the Study:
- To assess the feasibility of a structured, home-based exercise intervention in KTR at increased cardiometabolic risk.
- To evaluate recruitment, adherence, and retention rates for a home-based exercise program in KTR.
- To determine the safety and tolerability of a 12-week exercise program in KTR.
Main Methods:
- A randomized controlled trial (ECSERT) involving 50 KTR (>1-year post-transplant).
- Participants were randomized 1:1 to a 12-week home-based aerobic and resistance exercise program (INT) or guideline-directed care (CTR).
- Feasibility assessed by recruitment (≥20%), adherence (≥3 sessions/week), and attrition (≤30%).
Main Results:
- Recruitment exceeded targets, with 53% of eligible KTR (50/94) participating.
- Intervention participants achieved an average of 4.4 exercise sessions per week, surpassing the adherence threshold.
- Attrition was low at 8%, with no serious adverse events reported.
Conclusions:
- A structured, home-based exercise program is feasible and well-tolerated in kidney transplant recipients.
- Recruitment, adherence, and retention thresholds were successfully met, indicating program viability.
- This study supports further investigation and development of home-based exercise interventions for KTR to mitigate cardiometabolic risk.
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