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A Model of Intratumor and Interpatient Heterogeneity Explains Clinical Trials of Curative Combination Therapy for
Amy E Pomeroy1, Adam C Palmer1
1Department of Pharmacology, Computational Medicine Program, UNC Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
Blood Cancer Discovery
|February 24, 2025
Abstract
Significance:
A new model of intratumor and interpatient heterogeneity in response to drug combinations explains and predicts the results of clinical trials of curative-intent treatments for DLBCL. This model can be used to understand and inform optimal design of curative drug combinations and clinical trials. See related commentary by Goldstein et al., p. 153.
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