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Minimally invasive modalities for keratinocyte carcinomas-Part I: Diagnostics
Patrick McMullan1, Sarah Balboul1, Nathan Gasek1
1Department of Dermatology, University of Connecticut School of Medicine, Farmington, Connecticut.
Advancements in non-invasive diagnostic methods offer new ways to identify keratinocyte carcinoma, potentially reducing the need for skin biopsies in older and immunocompromised patients.
Area of Science:
- Dermatology
- Oncology
- Medical Diagnostics
Background:
- Keratinocyte carcinoma, including basal cell and squamous cell carcinoma, is the most common cancer in the US.
- Incidence is increasing in individuals over 65 and the immunocompromised.
Purpose of the Study:
- To review current and emerging non-invasive diagnostic methods for keratinocyte carcinoma.
- To highlight the benefits of these methods for specific patient populations.
Main Methods:
- Dermoscopy
- Reflectance confocal microscopy
- Optical coherence tomography
- Electrical impedance spectroscopy
- Tape-stripping for molecular analysis
- Artificial intelligence
Main Results:
- Non-invasive methods show promise in identifying keratinocyte carcinoma.
- These techniques can reduce the need for traditional skin biopsies.
Conclusions:
- Emerging non-invasive diagnostic tools offer alternatives to skin biopsies for keratinocyte carcinoma.
- These methods are valuable for patients with comorbidities, in sensitive cosmetic areas, or those with biopsy-related anxiety.
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