Photoinduced borylation of N-tosylhydrazones and application in drug derivation
Weijie Wang1,2, Qingguang Zhang2, Mengmeng Guo2
1School of Pharmacy, Ningxia Medical University, Yinchuan, Ningxia 750004, China. wdzhangy@hotmail.com.
Abstract:
The formation of carbon-boron bonds is a fundamental transformation in organic synthesis and the direct conversion of N-tosylhydrazones by photoinduced reactions is also a convenient and novel method. Herein, we report a mild strategy to access borylated compounds from aldehyde-derived N-tosylhydrazones, which proceeds without the need for any transition-metal catalysts under photoinduced conditions. Gram-scale synthesis and post-functionalization of drug analogues were achieved successfully, providing an approach to facilitate the fast modification of drugs.
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