Vaccines in Pregnancy: An Update on Recommendations From CDC's Advisory Committee on Immunization Practices

Vaccinations in pregnancy are an essential part of prenatal care and play a critical role in protecting both pregnant persons and their infants from certain infectious diseases. In the United States, recommendations for vaccines are made through a comprehensive review of currently available scientific literature, including clinical trials and post-marketing surveillance data, by the Advisory Committee on Immunization Practices (ACIP). The ACIP is an advisory committee to the US Centers for Disease Control and Prevention (CDC), comprised of medical and public health experts who develop evidence-based recommendations and guidelines for vaccinations, including for pregnant persons. The ACIP has several work groups that review scientific evidence on an ongoing basis, and full-committee public meetings are held at least three times a year. As more data regarding the safety and efficacy of vaccines in pregnancy become available, these recommendations continue to evolve. To develop these recommendations, the ACIP carefully considers the risks of exposure to infectious agents against the potential risks of vaccination. We review here current ACIP recommendations for vaccinations and their use in pregnant persons. Recommendations are divided into four categories: vaccines recommended during pregnancy, vaccines recommended during pregnancy under certain circumstances, vaccines not recommended or contraindicated during pregnancy, and vaccines without specific ACIP recommendations. To ensure optimal care during pregnancy, healthcare providers who care for pregnant persons need to be familiar with these recommendations.