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Emerging Roles for Transcription Factors During Mitosis
Samuel Flashner1, Jane Azizkhan-Clifford1
1Department of Biochemistry and Molecular Biology, Drexel University College of Medicine, Philadelphia, PA 19102, USA.
Cells
|February 25, 2025
Summary
Transcription factors are not mitotic spectators but actively regulate mitosis. Their roles in chromosome condensation and stability are crucial for preventing errors during cell division, impacting cancer development.
Area of Science:
- Cell Biology
- Molecular Biology
- Genetics
Background:
- Transcription factors were historically considered mitotic spectators, evicted from chromatin during mitosis.
- Emerging evidence reveals transcription factors actively participate in various mitotic processes.
Purpose of the Study:
- To review the dynamic roles of transcription factors and transcription during mitosis.
- To highlight their involvement in faithful sister chromatid segregation.
Main Methods:
- Literature review of existing research on transcription factors in mitosis.
- Analysis of evidence supporting active roles in chromosome dynamics and stability.
Main Results:
- Transcription factors actively regulate chromosome condensation, centromere/kinetochore function, and centrosome homeostasis.
- Mitotic inactivation of transcription factors leads to chromosome segregation errors and is linked to cancer.
- Active transcription during mitosis is vital for chromosomal stability.
Conclusions:
- Transcription factors are key regulators during mitosis, not passive bystanders.
- Understanding these roles is critical for addressing chromosomal instability and cancer.
Keywords:
aneuploidycentromerecentrosomechromosomal instabilitychromosome condensationchromosome segregationgenome instabilitykinetochoremitosistranscription factorMore Related Videos
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