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Updated: May 26, 2025

Author Spotlight: Advancements in DNA Nanosensors – Addressing Sensitivity and Selectivity Challenges in Molecular Detection
Published on: February 9, 2024
Metal Nanocluster-Based Biosensors for DNA Detection
Ran He1, Sheng Wang1, Feiye Ju1
1Hunan Key Laboratory of Biomedical Nanomaterials and Devices, College of Life Sciences and Chemistry, Hunan University of Technology, Zhuzhou 412007, China.
Abstract:
The early detection of genetic diseases is a critical need in modern medicine, underscoring the importance of developing deoxyribonucleic acid (DNA) biosensors. In recent years, metal nanoclusters (MNCs) have demonstrated significant potential as biosensors for DNA detection due to their ultra-small size, excellent photostability, bright photoluminescence, low toxicity and other outstanding properties. This review firstly discusses the characteristics of MNCs, which are effective in the early diagnosis of DNA diseases. Subsequently, different synthesis methods of MNCs are introduced. In the following section, DNA sensors based on different types of MNCs and their respective detection mechanisms are discussed in detail. Finally, the opportunities and challenges faced by DNA sensors based on MNCs are analyzed.

