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Prognostic Role of Pan-Immune-Inflammatory Value in Patients with Non-ST-Segment Elevation Acute Coronary Syndrome

Jeong Tae Byoun1, Kyeong Ho Yun1, Sungho Jo1

  • 1Departments of Cardiovascular Medicine, Regional Cardiocerebrovascular Center, Wonkwang University Hospital, Iksan 54538, Republic of Korea.

Journal of Cardiovascular Development and Disease
|February 25, 2025
PubMed

Insights

The pan-immune-inflammatory value (PIV) can predict major adverse cardiovascular events (MACEs) in acute coronary syndrome (ACS) patients. High PIV levels indicate a higher risk of MACEs within one year post-procedure.

Area of Science:

  • Cardiology
  • Inflammation Biomarkers
  • Clinical Outcomes Prediction

Background:

  • Blood cell-derived indices show promise in predicting cardiovascular outcomes.
  • Non-ST-segment elevation acute coronary syndrome (ACS) requires accurate prognostic tools.

Purpose of the Study:

  • To evaluate the prognostic value of the pan-immune-inflammatory value (PIV) for 1-year major adverse cardiovascular events (MACEs) in ACS patients.
  • To determine if PIV is an independent predictor of MACEs.

Main Methods:

  • Retrospective analysis of 1651 patients with non-ST-segment elevation ACS undergoing percutaneous coronary intervention.
  • Calculation of PIV from blood cell counts, with a cut-off value determined by ROC analysis.
  • Multivariate analysis to identify independent predictors of MACEs, including age, renal dysfunction, and PIV.

Main Results:

  • The incidence of MACEs was significantly higher in patients with high PIV (9.7%) compared to low PIV (5.0%) (p < 0.001).
  • High PIV (>256.3) was identified as an independent predictor of 1-year MACEs (HR 1.49, p = 0.048), alongside age and renal dysfunction.
  • Subgroup analyses showed no significant interaction between PIV and myocardial infarction status or C-reactive protein levels.

Conclusions:

  • The pan-immune-inflammatory value (PIV) is an independent predictor of 1-year MACEs in patients with non-ST-segment elevation ACS.
  • PIV may serve as a valuable prognostic marker, irrespective of myocardial infarction status or C-reactive protein levels.

Keywords:
acute coronary syndromebiomarkerslymphocytesneutrophilsplatelets

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