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Blood and Nerve Supply to the Kidney01:18

Blood and Nerve Supply to the Kidney

The kidneys are vital organs responsible for filtering and cleaning blood, removing waste products, and regulating electrolyte levels. To perform these essential functions, they require a constant and robust blood supply.
Bloody Supply to the Kidneys:
The kidneys receive their blood supply from the renal arteries, which branch off from the abdominal aorta—the main artery supplying the abdomen and lower body. The renal arteries enter the kidneys at the hilum, a notch on the medial side of each...

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Related Experiment Video

Updated: Jun 13, 2026

Optical Clearing and Imaging of Immunolabeled Kidney Tissue
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Multiphoton Microscopy to Visualize Live Renal Nerves in Reanimated Kidney Blocks.

Joerg Reifart1,2, Patrick T Willey3, Paul A Iaizzo1

  • 1Visible Heart® Laboratories, Department of Bioengineering, University of Minnesota, Minneapolis, MN 55455, USA.

Journal of Imaging
|February 25, 2025
PubMed
Summary

This study presents a novel method using multiphoton microscopy to visualize live renal nerves, aiding the development of better renal denervation devices for hypertension treatment.

Keywords:
isolated perfused kidneymultiphoton microscopyrenal arteryrenal denervation

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Area of Science:

  • Nephrology
  • Medical Imaging
  • Surgical Technology

Background:

  • Renal denervation shows inconsistent results for treating arterial hypertension.
  • Current methods lack ways to assess immediate renal denervation device success in living tissue.

Purpose of the Study:

  • To develop and evaluate a method for visualizing live renal nerves surrounding arteries using multiphoton microscopy.
  • To enable immediate assessment of renal denervation device efficacy in a viable tissue model.

Main Methods:

  • Explanted Yorkshire pig kidneys were maintained viable using a pulsatile perfusion system (Visible Kidney™ methodology).
  • Renal blocks underwent multiphoton microscopy with 780 nm excitation for autofluorescence imaging.
  • Peri-arterial nerves and arteriolar elastin fibers were visualized at 25× magnification.

Main Results:

  • Live peri-arterial renal nerves (2.5-23 μm diameter) were successfully imaged alongside arteriolar elastin fibers.
  • Imaging achieved a median signal-to-noise ratio of 52.3, though it was variable.
  • Autofluorescence was insufficient for nerve identification at 4× magnification.

Conclusions:

  • This multiphoton microscopy model provides a means to study live renal nerves in viable tissue.
  • The model holds potential for improving physician training and advancing renal denervation technologies.