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Related Experiment Video

Updated: May 26, 2026

Early Pathological and Magnetic Resonance Detection of Cerebral Injury Using a Rat Model of Neonatal Hypoxic Ischemic Encephalopathy

Early Pathological and Magnetic Resonance Detection of Cerebral Injury Using a Rat Model of Neonatal Hypoxic Ischemic Encephalopathy

Published on: October 28, 2022

Pediatric Wernicke Encephalopathy: A Systematic Review.

Erik Oudman^1,2, Jan W Wijnia^1,2, Janice R Bidesie^1,2

¹Experimental Psychology, Helmholtz Institute, Utrecht University, 3584 CS Utrecht, The Netherlands.

Pediatric Reports

|February 25, 2025

Summary

Pediatric Wernicke Encephalopathy (WE) can occur without alcohol. Early nausea and vomiting predict WE, and thiamine in parenteral nutrition is crucial for recovery, especially with optimal dosing.

Keywords:

Korsakoff syndrome Wernicke encephalopathy malnutrition parenteral nutrition prevention systematic review vitamin B1

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Published on: October 28, 2022

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A Pediatric Concussion Model in Mice: Closed Head Injury with Long-Term Disorders (CHILD)

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Published on: February 7, 2025

Area of Science:

Neurology
Pediatrics
Nutritional Science

Background:

Wernicke Encephalopathy (WE) is a neurological disorder typically associated with alcohol use.
Pediatric WE can arise from various non-alcoholic causes, including malnutrition and critical illnesses.

Purpose of the Study:

To systematically review pediatric Wernicke Encephalopathy cases.
To identify diverse etiologies and clinical presentations of pediatric WE.
To evaluate diagnostic and treatment outcomes for pediatric WE.

Main Methods:

Systematic review of 88 pediatric WE cases over 30 years.
Analysis of etiologies including cancer, gastrointestinal diseases, malnutrition, and COVID-19.
Review of clinical symptoms, diagnostic findings (MRI), and treatment protocols.

Main Results:

Nausea (60%) and vomiting (55%) were common prodromal symptoms.
37% received parenteral nutrition without thiamine before diagnosis, risking progression to Wernicke-Korsakoff syndrome (WKS).
Classic WKS triad (eye movement disorders, altered mental status, ataxia) present in most cases; MRI sensitivity 85%. Higher thiamine doses improved outcomes.

Conclusions:

Early recognition of nausea and vomiting is key for predicting pediatric WE.
Thiamine supplementation in parenteral nutrition is critical for preventing and treating pediatric WE.
Optimal thiamine dosing is vital for patient recovery and improved outcomes.