Related Experiment Video
Updated: May 26, 2025
07:32
Human Ex vivo Wound Model and Whole-Mount Staining Approach to Accurately Evaluate Skin Repair
Published on: February 17, 2021
6.9K
Endocrine Controls of Skin Aging
Markus Böhm1, Agatha Stegemann1, Ralf Paus2,3,4,5
1Department of Dermatology, University of Münster, Münster 48149, Germany.
Endocrine Reviews
|February 25, 2025
Summary
Skin aging involves intrinsic and extrinsic factors, influenced by hormones. Research highlights key hormones like IGF-1, GH, estrogens, and melatonin, offering potential for new anti-aging therapies.
Area of Science:
- Dermatology and endocrinology.
- Focus on skin aging mechanisms and hormonal regulation.
Background:
- Skin aging results from intrinsic (genetic) and extrinsic (exposome) factors.
- Both aging types share biochemical changes like oxidative stress and DNA damage.
- Skin and hair follicles act as endocrine organs, influenced by neuroendocrine axes.
Purpose of the Study:
- To review pivotal hormones that control human skin aging.
- To explore the roles of both classical and emerging endocrine players.
- To identify potential targets for novel anti-skin aging therapeutics.
Main Methods:
- Comprehensive literature review of hormonal influences on skin aging.
- Analysis of molecular and biochemical processes.
- Evaluation of current clinical applications and future research directions.
Main Results:
- Key hormones reviewed include IGF-1, GH, estrogens, and melatonin.
- Emerging roles of α-MSH, thyroid axis hormones, oxytocin, endocannabinoids, and PPAR modulators are discussed.
- Topical retinoids and estrogens are currently the primary hormonal anti-aging treatments.
Conclusions:
- Hormonal regulation is crucial in both intrinsic and extrinsic skin aging.
- Further research into endocrine players and derivatives may yield novel senotherapeutics.
- Targeting hormonal pathways presents a promising avenue for skin aging prevention and treatment.
Related Concept Videos
01:12Renewal of Skin Epidermal Stem Cells
2.4K
The skin is divided into epidermis, dermis, and hypodermis, the skin's outermost, middle, and inner layers. The human epidermal layer regularly undergoes renewal, where old, dead cells are replaced by new cells. Epidermal stem cells or EpiSCs divide and differentiate to restore the lost cells. For the renewal process, some EpiSCs continuously self-renew. In contrast, few others differentiate into transit-amplifying cells, which later form prickle or spinous cells, followed by granular...
2.4K
01:19The Effect of Aging on Tissues
2.0K
Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
2.0K
01:19Pigmentation
2.3K
The color of the skin is influenced by a number of pigments, including melanin, carotene, and hemoglobin. Recall that melanin is produced by cells called melanocytes, which are found scattered throughout the stratum basale of the epidermis. The melanin is transferred to the keratinocytes via melanosomes.
Melanin occurs in two primary forms: eumelanin that provides black and brown pigment and pheomelanin that provides red color. Dark-skinned individuals produce more melanin than those with pale...
Melanin occurs in two primary forms: eumelanin that provides black and brown pigment and pheomelanin that provides red color. Dark-skinned individuals produce more melanin than those with pale...
2.3K
01:26Aging
35
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
35
01:23Role of Skin in Vitamin D Synthesis
5.0K
The skin plays a crucial role in the synthesis of vitamin D, a vital nutrient for various physiological processes in the body. Vitamin D is unique because it can be synthesized in the skin through a series of chemical reactions triggered by exposure to ultraviolet B (UVB) radiation from sunlight.
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin...
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin...
5.0K
01:27Major Hormones and Their Functions
284
Hormones, the biochemical messengers produced by endocrine glands, are pivotal in regulating bodily functions and maintaining homeostasis. Each hormone's balance is crucial; imbalances can lead to significant physiological disruptions. Major hormones include oxytocin, cortisol, epinephrine, estrogen, testosterone, thyroxine, growth hormone, insulin, and glucagon.
Oxytocin, produced in the hypothalamus and released by the pituitary gland, plays a role in social bonding, childbirth, and...
Oxytocin, produced in the hypothalamus and released by the pituitary gland, plays a role in social bonding, childbirth, and...
284