Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

FULL-THICKNESS MACULAR HOLE FORMATION FOLLOWING PANRETINAL PHOTOCOAGULATION FOR PROLIFERATIVE DIABETIC RETINOPATHY.

Retinal cases & brief reports·2023
Same author

OCULAR BARTONELLOSIS PRESENTING WITH FOCAL CHOROIDITIS, FOCAL RETINITIS, BRANCH RETINAL ARTERY OCCLUSION, AND PARACENTRAL ACUTE MIDDLE MACULOPATHY: LONGITUDINAL MULTIMODAL IMAGING ANALYSIS.

Retinal cases & brief reports·2022
Same author

Glaucoma public service announcements: factors associated with follow-up of participants with risk factors for glaucoma.

Ophthalmology·2011
See all related articles

Related Experiment Video

Updated: May 26, 2025

Subretinal Transplantation of Human Embryonic Stem Cell Derived-retinal Pigment Epithelial Cells into a Large-eyed Model of Geographic Atrophy
11:03

Subretinal Transplantation of Human Embryonic Stem Cell Derived-retinal Pigment Epithelial Cells into a Large-eyed Model of Geographic Atrophy

Published on: January 22, 2018

10.0K

RETINAL TOXICITY SECONDARY TO INADVERTENT SUBRETINAL MITOMYCIN C INJECTION.

Joseph B Alsberge1, Zakary Hoffelt

  • 1Department of Ophthalmology, Northwest Permanente, Vancouver, Washington.

Retinal Cases & Brief Reports
|February 25, 2025
PubMed
Summary

Accidental injection of mitomycin C (MMC) into the subretinal space during glaucoma surgery can cause localized retinal toxicity. This case highlights the risk of subretinal placement, leading to chorioretinal atrophy despite preserved visual acuity.

More Related Videos

Intraoperative Visualization of Subretinal Injection and Retinal Detachment in Rats
04:16

Intraoperative Visualization of Subretinal Injection and Retinal Detachment in Rats

Published on: March 7, 2025

219
An Alternative and Validated Injection Method for Accessing the Subretinal Space via a Transcleral Posterior Approach
07:13

An Alternative and Validated Injection Method for Accessing the Subretinal Space via a Transcleral Posterior Approach

Published on: December 7, 2016

13.1K

Related Experiment Videos

Last Updated: May 26, 2025

Subretinal Transplantation of Human Embryonic Stem Cell Derived-retinal Pigment Epithelial Cells into a Large-eyed Model of Geographic Atrophy
11:03

Subretinal Transplantation of Human Embryonic Stem Cell Derived-retinal Pigment Epithelial Cells into a Large-eyed Model of Geographic Atrophy

Published on: January 22, 2018

10.0K
Intraoperative Visualization of Subretinal Injection and Retinal Detachment in Rats
04:16

Intraoperative Visualization of Subretinal Injection and Retinal Detachment in Rats

Published on: March 7, 2025

219
An Alternative and Validated Injection Method for Accessing the Subretinal Space via a Transcleral Posterior Approach
07:13

An Alternative and Validated Injection Method for Accessing the Subretinal Space via a Transcleral Posterior Approach

Published on: December 7, 2016

13.1K

Area of Science:

  • Ophthalmology
  • Retinal Surgery
  • Glaucoma Management

Background:

  • Mitomycin C (MMC) is commonly used in glaucoma surgery to enhance surgical outcomes.
  • Sub-Tenon injections are standard for delivering MMC to modulate scarring.
  • Potential complications of ocular injections require careful consideration.

Purpose of the Study:

  • To document a case of retinal toxicity resulting from inadvertent subretinal injection of mitomycin C.
  • To review the literature on complications associated with mitomycin C administration in ocular procedures.
  • To emphasize the importance of precise injection technique in glaucoma surgery.

Main Methods:

  • A case report of a patient who experienced adverse effects after mitomycin C injection.
  • Review of existing medical literature pertaining to mitomycin C-induced ocular toxicity.
  • Clinical examination and imaging to assess the extent of retinal damage.

Main Results:

  • A 73-year-old male developed localized retinal edema, hemorrhages, and occlusive vasculopathy post-glaucoma surgery.
  • The complication was attributed to inadvertent subretinal placement of mitomycin C due to scleral puncture.
  • Chorioretinal atrophy was observed at one month, but the macula was spared, and visual acuity remained stable.

Conclusions:

  • Inadvertent subretinal administration of mitomycin C can occur during attempted sub-Tenon injections.
  • Subretinal mitomycin C can lead to significant, localized retinal toxicity and chorioretinal changes.
  • Vigilance in injection technique is crucial to prevent severe ocular complications in glaucoma surgery.