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Maternal vitamin D status in relation to cardiometabolic risk factors in children from the Norwegian Environmental

Anna Amberntsson1, Linnea Bärebring1, Anna Winkvist1

  • 1Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

Plos One
|February 25, 2025
PubMed

Insights

Higher maternal vitamin D levels in pregnancy were linked to increased childhood adiponectin levels. This study explored the vitamin D and child cardiometabolic health connection.

Area of Science:

  • Reproductive Health
  • Pediatric Endocrinology
  • Nutritional Science

Background:

  • Maternal 25-hydroxyvitamin D (25OHD) status during pregnancy is linked to birth weight and childhood growth.
  • Maternal vitamin D may influence childhood cardiometabolic health.
  • This study examines the relationship between maternal 25OHD and childhood cardiometabolic risk markers.

Purpose of the Study:

  • To investigate the association between maternal 25-hydroxyvitamin D (25OHD) levels during pregnancy and cardiometabolic risk factors in children aged 7-12.
  • To explore potential links between prenatal vitamin D exposure and markers of metabolic health in offspring.

Main Methods:

  • Utilized data from 244 mother-child pairs in the Norwegian Mother, Father and Child Cohort Study (MoBa).
  • Assessed childhood outcomes including anthropometrics, blood lipids, and hormones (z-scores).
  • Employed linear regression, adjusting for covariates like maternal BMI and education, to analyze associations between maternal 25OHD and child cardiometabolic factors.

Main Results:

  • A 10 nmol/L increase in maternal 25OHD was associated with a 0.067 standard deviation increase in childhood adiponectin z-score (p=0.039).
  • No significant associations were found between maternal 25OHD concentration and other childhood cardiometabolic risk factors.

Conclusions:

  • Higher maternal vitamin D status in pregnancy may correlate with elevated childhood adiponectin z-scores.
  • The findings suggest a potential, yet unconfirmed, role for adiponectin in mediating the effects of vitamin D on cardiometabolic health.
  • Further research is needed to elucidate the pathway linking maternal vitamin D and child cardiometabolic outcomes.
Abstract

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