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Updated: May 26, 2025

Comparing the Affinity of GTPase-binding Proteins using Competition Assays
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Disordered C-Terminus Plays a Critical Role in the Activity of the Small GTPase Ran

Wenyuan Wei1,2, Melissa Valerio2,3, Ning Ma1

  • 1Department of Computational and Quantitative Medicine, Beckman Research Institute of the City of Hope, Duarte, California 91010, United States.

Biochemistry
|February 25, 2025
PubMed
Summary

Researchers identified key interactions in the Ran protein's C-terminus, crucial for regulating its activity. This discovery enables the development of new drugs targeting leukemia stem cells by inhibiting Ran-mediated transport.

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