Self-supervised learning for graph-structured data in healthcare applications: A comprehensive review

The increasing complexity and interconnectedness of healthcare data present numerous opportunities to improve prediction, diagnosis, and treatment. Graph-structured data, which represents entities and their relationships, is well-suited for modeling these complex connections. However, effectively utilizing this data often requires strong and efficient learning algorithms, especially when dealing with limited labeled data. Self-supervised learning (SSL) has emerged as a powerful paradigm for leveraging unlabeled data to learn effective representations. This paper presents a comprehensive review of SSL approaches specifically designed for graph-structured data in healthcare applications. We explore the challenges and opportunities associated with healthcare data and assess the effectiveness of SSL techniques in real-world healthcare applications. Our discussion encompasses various healthcare settings, such as disease prediction, medical image analysis, and drug discovery. We critically evaluate the performance of different SSL methods across these tasks, highlighting their strengths, limitations, and potential future research directions. To the best of our knowledge, this is the first comprehensive review of SSL applied to graph data in healthcare, providing valuable guidance for researchers and practitioners looking to leverage these techniques to enhance outcomes and drive progress in the field.