Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Dementia01:30

Dementia

88
Dementia is a collective term for cognitive disorders primarily affecting memory, thinking, and reasoning. It is not a specific disease but a syndrome, with Alzheimer's disease being the most common cause, accounting for approximately 60-80% of cases. Other types include vascular dementia, Lewy body dementia, and frontotemporal dementia. Dementia affects millions worldwide, particularly older adults, though it is not a normal part of aging.
The progression of dementia is generally gradual....
88
Alzheimer's Disease: Overview01:26

Alzheimer's Disease: Overview

422
Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
422
Alzheimer's Disease: Treatment01:22

Alzheimer's Disease: Treatment

147
Alzheimer's Disease (AD), a neurodegenerative disorder, is pathologically identified by amyloid plaques and neurofibrillary tangles composed of tau protein. AD pharmacotherapy aims to manage cognitive symptoms, delay disease progression, and treat behavioral symptoms. The treatment is primarily symptomatic and palliative, with no definitive disease-modifying therapy available. Cholinesterase inhibitors, including donepezil (Aricept), rivastigmine (Exelon), and galantamine (Razadyne), are...
147
Vascular Spasm01:16

Vascular Spasm

1.1K
The vascular phase, also known as vasospasm, is the initial stage of hemostasis, crucial for preventing excessive bleeding when a blood vessel is injured. After a vessel is cut, nerves in the damaged area trigger pain and other sensory impulses. Simultaneously, the smooth muscles in the vessel wall contract, resulting in a vascular spasm. This contraction reduces the vessel's diameter at the injury site, slowing or stopping blood loss through the vessel wall. Vascular spasms typically last...
1.1K
Regulation of Stroke Volume01:27

Regulation of Stroke Volume

3.1K
The regulation of stroke volume, which is the amount of blood the heart pumps out during each heartbeat, is critical for maintaining a healthy circulatory system. Stroke volume is influenced by three main factors: preload, contractility, and afterload.
Preload refers to the degree of stretch on the heart before it contracts. It's analogous to the stretching of a rubber band; the more it's stretched, the more forcefully it snaps back. This concept is encapsulated in the Frank-Starling law of the...
3.1K
Ischemic Heart Disease: Overview01:17

Ischemic Heart Disease: Overview

1.1K
Ischemic heart disease occurs when the heart's blood supply dwindles, causing an ominous lack of oxygen and nutrients. This deficiency, stemming from reduced or obstructed blood flow, spells danger, leading to heart muscle damage and dysfunction.
Atherosclerosis, the primary malefactor, orchestrates this dangerous condition. It manifests as the accumulation of fatty deposits, akin to insidious plaques, within arterial walls. As time elapses, these plaques metamorphose, hardening and...
1.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Elevated CSF Beta Trace Protein Levels in Patients with CSF-Venous Fistulas.

AJNR. American journal of neuroradiology·2026
Same author

Transcranial Direct Current Stimulation for Stroke Motor Recovery What the TRANSPORT2 Trial Taught Us.

Stroke·2026
Same author

Global Pediatric Stroke Epidemiology: A Systematic Review of the Literature and Meta-Analysis.

Journal of child neurology·2026
Same author

Clinical Presentation, Misdiagnosis, and Imaging Findings of Anterior Disc Herniations.

AJNR. American journal of neuroradiology·2026
Same author

Prognostic Value of Interim PSMA-PET Total Tumor Volume for Overall Survival Within ENZA-p, A Randomized Phase 2 Trial of Enzalutamide Versus Enzalutamide Plus [<sup>177</sup>Lu] Lu-PSMA-617 (ANZUP1901).

European urology·2026
Same author

Predictors of motor outcome with pallidal stimulation for Parkinson's disease from the CSP468 cohort.

NPJ Parkinson's disease·2026
Same journal

ZL006-05 prevents tPA-induced haemorrhagic transformation after stroke via inhibiting neutrophil myeloperoxidase-related pathway.

Stroke and vascular neurology·2026
Same journal

Cough reflex testing for dysphagia severity and pneumonia risk after acute stroke: a prospective observational study.

Stroke and vascular neurology·2026
Same journal

Chinese stroke association guidelines on construction of direct transfer to angiography suite.

Stroke and vascular neurology·2026
Same journal

Development and validation of an explainable prediction model for post-stroke epilepsy in patients with ischaemic stroke following mechanical thrombectomy: a multicentre retrospective cohort study.

Stroke and vascular neurology·2026
Same journal

Endothelial dysfunction mediates inflammation-driven poor prognosis in symptomatic intracranial atherosclerosis stenosis.

Stroke and vascular neurology·2026
Same journal

Piezo1 mechanosensitive ion channel in macrophages: a potential therapeutic target for intracerebral haemorrhage.

Stroke and vascular neurology·2026
See all related articles

Related Experiment Video

Updated: May 25, 2025

Using Retinal Imaging to Study Dementia
09:17

Using Retinal Imaging to Study Dementia

Published on: November 6, 2017

21.4K

Updates on vascular dementia.

Sabrina Ng1,2, Ava Hornblass1,2, Parnian Habibi3,4

  • 1Department of Neurology, Icahn School of Medicine, New York, New York, USA.

Stroke and Vascular Neurology
|February 25, 2025
PubMed
Summary
This summary is machine-generated.

Vascular dementia (VaD) incidence is declining due to better cardiovascular health. Research explores VaD mechanisms, risk factors, and new treatments like stem cells, aiming to slow its progression.

Keywords:
Cerebrovascular DisordersCognitive DysfunctionNeurodegenerative DiseasesSystematic Review

More Related Videos

A Mouse Model for Vascular Cognitive Impairment and Dementia Based on Needle-guided Asymmetric Bilateral Common Carotid Artery Stenosis
05:19

A Mouse Model for Vascular Cognitive Impairment and Dementia Based on Needle-guided Asymmetric Bilateral Common Carotid Artery Stenosis

Published on: November 22, 2024

384
Evaluation of the Cognitive Performance of Hypertensive Patients with Silent Cerebrovascular Lesions
07:30

Evaluation of the Cognitive Performance of Hypertensive Patients with Silent Cerebrovascular Lesions

Published on: April 23, 2021

2.9K

Related Experiment Videos

Last Updated: May 25, 2025

Using Retinal Imaging to Study Dementia
09:17

Using Retinal Imaging to Study Dementia

Published on: November 6, 2017

21.4K
A Mouse Model for Vascular Cognitive Impairment and Dementia Based on Needle-guided Asymmetric Bilateral Common Carotid Artery Stenosis
05:19

A Mouse Model for Vascular Cognitive Impairment and Dementia Based on Needle-guided Asymmetric Bilateral Common Carotid Artery Stenosis

Published on: November 22, 2024

384
Evaluation of the Cognitive Performance of Hypertensive Patients with Silent Cerebrovascular Lesions
07:30

Evaluation of the Cognitive Performance of Hypertensive Patients with Silent Cerebrovascular Lesions

Published on: April 23, 2021

2.9K

Area of Science:

  • Neurology
  • Gerontology
  • Cardiovascular Medicine

Background:

  • Vascular dementia (VaD) is the second most common dementia type, following Alzheimer's disease (AD).
  • Improvements in managing cardiovascular risk factors have led to a decreased incidence of VaD compared to AD.
  • While vascular pathologies causing brain hypoperfusion and hypoxia are primary suspected mechanisms, neuroinflammation may also play a role.

Purpose of the Study:

  • To review current knowledge on VaD epidemiology, risk factors, and disease mechanisms.
  • To highlight the significance of lifestyle modifications and comorbidity management in VaD prevention and progression.
  • To summarize existing treatments and emerging therapeutic strategies for VaD.

Main Methods:

  • Narrative review of existing literature on vascular dementia.
  • Analysis of epidemiological data and risk factors.
  • Examination of current and investigational therapeutic approaches.

Main Results:

  • VaD incidence is decreasing due to improved cardiovascular health management.
  • Clinical presentation of VaD often overlaps with AD, posing diagnostic challenges.
  • Biomarkers are being developed to aid in differentiating VaD from other dementias.
  • Current treatments for VaD are largely symptomatic, lacking disease-modifying agents.

Conclusions:

  • Optimizing lifestyle and managing comorbid conditions are crucial for preventing or slowing VaD.
  • Novel therapies, including stem-cell therapy and neuromodulation, are under investigation.
  • Further research is needed to develop effective treatments that target the underlying mechanisms of VaD.