Postbiotics from Saccharomyces cerevisiae RC016 Cell Wall (Formerly Classified as a Prebiotic): Exploring In Vitro...

Area of Science:

• Microbiology
• Food Science
• Animal Science

Background:

• Postbiotics, derived from microorganisms, offer potential health benefits without microbial administration.
• Saccharomyces cerevisiae cell walls are a rich source of bioactive compounds.
• Understanding postbiotic production and efficacy is crucial for their application in animal feed and human health.

Purpose of the Study:

• To obtain and characterize postbiotics from Saccharomyces cerevisiae RC016 cell walls.
• To evaluate the in vitro antitoxin capacity and in vivo impact on intestinal integrity.
• To analyze the effect of drying methods on toxin adsorption properties.

Main Methods:

• Nine mechanical and enzymatic treatments were used to extract postbiotics from Saccharomyces cerevisiae RC016 biomass.
• In vitro studies assessed antitoxin activity against aflatoxin B1 (adsorption and degradation).
• In vivo studies on BALB/c mice evaluated microbiota modulation and intestinal histomorphometry.

Main Results:

• Postbiotics exhibited in vitro antitoxin activity against aflatoxin B1.
• Significant differences in intestinal microbiota were observed between male and female mice.
• Male mice receiving postbiotics showed increased villi height, width, and crypt depth.

Conclusions:

• Postbiotics derived from Saccharomyces cerevisiae cell walls can positively impact intestinal integrity, particularly in male mice.
• The study highlights the potential of these postbiotics as functional ingredients.
• Further research can optimize production and explore broader applications across different populations.