Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Combined Effects of Drugs: Synergism01:27

Combined Effects of Drugs: Synergism

3.7K
Synergism is a useful mechanism where combining two or more drugs is more effective than each constituent used alone. Such combinations are also called supra-additive interactions. The drugs collectively enhance the final therapeutic effect by acting on different targets. Another advantage is that the low dose of each constituent drug is sufficient to achieve the desired effect. This helps reduce the duration of therapy and lower the adverse effects of these drugs.
Such synergistic combinations...
3.7K
Antimicrobial Proteins01:23

Antimicrobial Proteins

867
Antimicrobial proteins are important components of the immune system. They aid the body in combating pathogens by either killing them directly or hindering their replication processes. Four main types of antimicrobial substances are interferons, the complement system, iron-binding proteins, and antimicrobial proteins.
Interferons
Interferons (IFNs) are proteins produced by lymphocytes, macrophages, and fibroblasts infected with viruses. While IFNs cannot prevent viruses from entering and...
867
Hand hygiene01:23

Hand hygiene

3.1K
Asepsis is the practice of preventing or breaking the chain of infection. The nurse employs aseptic techniques to prevent the spread of microorganisms and reduce the risk of diseases. Hand hygiene is the cornerstone of aseptic techniques and is classified into medical and surgical asepsis. Medical asepsis includes hand hygiene and the use of gloves. Surgical asepsis, or the sterile technique, refers to practices that render and keep objects and areas free of microorganisms.
Hand washing...
3.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Peptide-Based Delivery Systems: Selected Insights into Cell-Penetrating Peptides.

ACS chemical neuroscience·2026
Same author

Racemisation of Amino Acids: From Synthetic Challenge to Biological Significance.

Chembiochem : a European journal of chemical biology·2026
Same author

Self-Assembly of Peptides and Biomolecular Systems Into Functional Nanomaterials.

Journal of peptide science : an official publication of the European Peptide Society·2026
Same author

Application of the OBIMAP (One-Bead Interchain Multipeptide Assembly Platform) to Long Peptide Synthesis: Liraglutide as a Case Study.

ACS omega·2026
Same author

2025 FDA TIDES (Peptides and Oligonucleotides) Harvest.

Pharmaceuticals (Basel, Switzerland)·2026
Same author

OBIMAP (One-Bead Interchain Multipeptide Assembly Platform).

ACS bio & med chem Au·2026

Related Experiment Video

Updated: May 25, 2025

Whole Genome Sequencing of Candida glabrata for Detection of Markers of Antifungal Drug Resistance
08:45

Whole Genome Sequencing of Candida glabrata for Detection of Markers of Antifungal Drug Resistance

Published on: December 28, 2017

13.6K

FDA-Approved Antibacterials and Echinocandins.

Othman Al Musaimi1,2

  • 1School of Pharmacy, Newcastle University, Newcastle upon Tyne NE1 7RU, UK.

Antibiotics (Basel, Switzerland)
|February 26, 2025
PubMed
Summary

Antimicrobial and antifungal peptides are effective treatments for serious infections. Ongoing research and recent approvals highlight their growing importance in medicine, with many more in clinical trials.

Keywords:
FDAantimicrobialbacteriaechinocandinfunguspeptidespharmaceuticals

More Related Videos

Author Spotlight: Scalable Drug Screening Protocol for Efficient Discovery of M. abscessus Treatments
07:50

Author Spotlight: Scalable Drug Screening Protocol for Efficient Discovery of M. abscessus Treatments

Published on: October 25, 2024

1.5K
Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
11:17

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses

Published on: August 30, 2018

12.8K

Related Experiment Videos

Last Updated: May 25, 2025

Whole Genome Sequencing of Candida glabrata for Detection of Markers of Antifungal Drug Resistance
08:45

Whole Genome Sequencing of Candida glabrata for Detection of Markers of Antifungal Drug Resistance

Published on: December 28, 2017

13.6K
Author Spotlight: Scalable Drug Screening Protocol for Efficient Discovery of M. abscessus Treatments
07:50

Author Spotlight: Scalable Drug Screening Protocol for Efficient Discovery of M. abscessus Treatments

Published on: October 25, 2024

1.5K
Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
11:17

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses

Published on: August 30, 2018

12.8K

Area of Science:

  • Pharmacology and Drug Development
  • Infectious Diseases
  • Biochemistry

Background:

  • Peptide-based therapeutics offer novel mechanisms for combating microbial and fungal infections.
  • The Food and Drug Administration (FDA) has approved 12 such agents since 1955.
  • Recent approvals, including an echinocandin peptide, underscore their continued relevance.

Purpose of the Study:

  • To review antimicrobial and antifungal peptides.
  • To analyze their chemical structure, indications, and mechanisms of action.
  • To trace their development journey to market.

Main Methods:

  • Literature review of approved and investigational peptide therapeutics.
  • Analysis of chemical properties, clinical trial data, and regulatory approvals.
  • Synthesis of information on peptide drug development pathways.

Main Results:

  • Twelve peptide drugs with antimicrobial/antifungal properties have FDA approval.
  • Twenty-two additional peptide therapeutics are in clinical trials.
  • Peptides utilize diverse and sometimes multiple mechanisms to combat infections.

Conclusions:

  • Peptide therapeutics represent a vital and expanding class of drugs for treating challenging infections.
  • The development pipeline indicates sustained innovation and future potential for peptide-based medicines.
  • Continued research into peptide structure, function, and delivery is crucial for pharmaceutical advancement.