Image Quality in Adaptive Optics Optical Coherence Tomography of Diabetic Patients

Background/Objectives: An assessment of the retinal image quality in adaptive optics optical coherence tomography (AO-OCT) is challenging. Many factors influence AO-OCT imaging performance, leading to greatly varying imaging results, even in the same subject. The aim of this study is to introduce quantitative means for an assessment of AO-OCT image quality and to compare these with parameters retrieved from the pyramid wavefront sensor of the system. Methods: We used a spectral domain AO-OCT instrument to repetitively image six patients suffering from diabetic retinopathy over a time span of one year. The data evaluation consists of two volume acquisitions with a focus on the photoreceptor layer, each at five different retinal locations per visit; 7-8 visits per patient are included in this data analysis, resulting in a total of ~420 volumes. Results: A large variability in AO-OCT image quality is observed between subjects and between visits of the same subject. On average, the image quality does not depend on the measurement location. The data show a moderate correlation between the axial position of the volume recording and image quality. The correlation between pupil size and AO-OCT image quality is not linear. A weak correlation is found between the signal-to-noise ratio of the wavefront sensor image and the image quality. Conclusions: The introduced AO-OCT image quality metric gives useful insights into the performance of such a system. A longitudinal assessment of this metric, together with wavefront sensor data, is essential to identify factors influencing image quality and, in the next step, to optimize the performance of AO-OCT systems.