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Immune-Mediated Bidirectional Causality Between Inflammatory Bowel Disease and Chronic Periodontitis: Evidence from
Zhijun Feng1, Zihan Chen1, Xiaoxu Wang1
1Department of Radiation Medicine, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, Guangzhou 510515, China.
Biomedicines
|February 26, 2025
Summary
Genetic analysis reveals a two-way causal link between inflammatory bowel disease (IBD) and periodontitis. Shared molecular pathways and immune regulators like IL1B and CXCR4 underpin this relationship, suggesting new therapeutic targets.
Area of Science:
- Immunology
- Genetics
- Gastroenterology
- Periodontology
Background:
- A bidirectional association exists between inflammatory bowel disease (IBD) and periodontitis.
- The precise causal relationship between these two inflammatory conditions requires further elucidation.
Purpose of the Study:
- To investigate the potential causal links between IBD and periodontitis.
- To explore shared genetic and molecular mechanisms underlying both diseases.
Main Methods:
- Bidirectional Mendelian randomization (MR) analysis was employed.
- Bioinformatics approaches, including differential gene expression and pathway enrichment analysis, were utilized.
- Inverse variance weighting (IVW) and sensitivity analyses assessed causal associations and robustness.
Main Results:
- Significant bidirectional causal associations were identified between IBD and periodontitis.
- Key immune regulators (IL1B, CXCR4) and inflammatory pathways (TNF-α, IL17) were implicated.
- Transcriptomic analysis revealed shared pathological mechanisms and inflammatory mediators.
Conclusions:
- Genetic evidence supports a bidirectional causal relationship between IBD and periodontitis.
- Shared molecular mechanisms and immune factors provide insight into the interplay between these conditions.
- Findings may inform novel therapeutic strategies for IBD and periodontitis.
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