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Clinical Associations with Lenticulostriatal Vasculopathy (LSV) at Birth: A Case-Control Study
Aikaterini Kyriakopoulou1, Kyriakos Samikos2, Aikaterini Kanavaki2
1Third Department of Pediatrics, Attikon General University Hospital, National and Kapodistrian University of Athens, 124 62 Athens, Greece.
Children (Basel, Switzerland)
|February 26, 2025
Summary
This study found that Lissencephaly-like Sonographic Variations (LSV) in neonates are linked to larger head circumference and body length. Further research is needed to understand the causes of LSV.
Area of Science:
- Neonatal Neurology
- Pediatric Imaging
- Clinical Genetics
Background:
- Lissencephaly-like Sonographic Variations (LSV) are a group of brain abnormalities observed in neonates.
- Understanding the clinical characteristics associated with LSV is crucial for early diagnosis and management.
- Previous studies have explored various factors, but a comprehensive analysis of birth characteristics is needed.
Purpose of the Study:
- To investigate the clinical characteristics associated with the presence of LSV at birth in premature neonates.
- To identify potential correlations between LSV and specific neonatal anthropometric measurements and clinical findings.
Main Methods:
- A prospective 1:1 case-control study was conducted in two tertiary neonatal units.
- Premature neonates (≤36 weeks gestational age) with LSV detected via cerebral ultrasound were compared to controls.
- Analyses included unmatched and matched comparisons, stratifying by gestational week, using the likelihood ratio test.
Main Results:
- The study included 166 neonates (83 cases with LSV, 83 controls).
- Neonates with LSV showed a higher incidence of concurrent cerebral findings, particularly periventricular echogenicity.
- LSV was significantly correlated with increased z-scores for head circumference and body length, but not with congenital CMV.
Conclusions:
- LSV at birth is associated with increased head circumference and body length in premature neonates.
- The findings suggest a potential link between LSV and growth parameters.
- Further research is recommended to elucidate the pathophysiological mechanisms underlying LSV.
