Modulation of Primary Afferent Nerve Fiber (Ia) Reciprocal Inhibition Under Voluntary and Electrically Stimulated...

Background: Reciprocal inhibition (RI) is a spinal reflex that controls posture and movement. The modulation of spinal RI represented by the H-reflex has been studied, before and after voluntary contraction and electrical nerve stimulation but not during voluntary, electrically induced muscle contraction or a combination of voluntary and electrically induced muscle contractions. This study investigates the effects of the ongoing voluntary isometric contraction, the electrically induced isometric contraction, and the combination of voluntary with electrically induced isometric contraction of the Tibialis Anterior (TA) muscle on spinal RI represented by Soleus H-reflex. Methods: Eighteen healthy adults participated. Soleus H-reflex and M-response were measured during four different conditions as follows: (1) at rest, (2) electrically induced isometric contraction of the TA, (3) voluntary isometric contraction of the TA with a 1 kg force, and (4) combined voluntary and electrically induced isometric contraction of the TA with a 1 kg force. Results: The ANOVA clearly demonstrated significant differences in Soleus H-reflex amplitude across the four recording conditions (F3,16, 17.28, p < 0.001). The amplitude at rest was significantly higher than during electrically induced isometric contraction, voluntary isometric contraction, and the combined contraction conditions (p < 0.05). Furthermore, the amplitude recorded during the electrically induced isometric contraction condition significantly surpassed that of voluntary isometric contraction and the combined contraction conditions (p < 0.05). Moreover, there was no significant difference between Soleus H-reflex amplitude recorded during voluntary isometric contraction and the combined voluntary isometric contraction and electrically induced isometric contraction (p < 0.87). The combined voluntary isometric contraction and electrically induced isometric contraction condition had a higher inhibitory effect on the Soleus H-reflex with no significant differences from voluntary isometric contraction. Moreover, both were significantly better than electrically induced isometric contraction (p = 0.05). In terms of Soleus H-reflex latency, there was no significant difference among all four conditions (p > 0.05), meaning Soleus H-reflex latency was not influenced by the conditions. Conclusions: RI can be best modulated by combining voluntary with electrically induced isometric muscle contractions.