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Combination Therapies and Personalized Medicine

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Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...

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Tumor Treating Field Therapy in Combination with Bevacizumab for the Treatment of Recurrent Glioblastoma

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Personalized Treatment for Scalp Angiosarcoma.

Adriana Nicoleta Cristescu¹, Ioana Dumitrescu², Irina Tudose³

¹Dermatology Department, Elias Emergency University Hospital, 17 Marasti Bd., District 1, 011461 Bucharest, Romania.

Journal of Clinical Medicine

|February 26, 2025

Summary

This summary is machine-generated.

Cutaneous angiosarcoma, a rare scalp tumor, is often missed due to vague symptoms. Early diagnosis and personalized, multimodal treatment are vital for better outcomes in this aggressive cancer.

Keywords:

angiosarcoma radiotherapy scalp surgery

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Area of Science:

Oncology
Dermatology
Surgical Pathology

Background:

Cutaneous angiosarcoma is a rare, aggressive vascular tumor.
It frequently affects the head and neck, especially the scalp.
Rarity and non-specific symptoms often lead to delayed diagnosis.

Purpose of the Study:

To review literature on individualized management of cutaneous angiosarcoma.
To share clinical experiences in managing this rare tumor.
To emphasize early detection and diagnosis of scalp angiosarcoma.

Main Methods:

Literature review of cutaneous angiosarcoma management.
Analysis of clinical cases and treatment approaches.
Discussion of multimodal therapeutic strategies.

Main Results:

Cutaneous angiosarcoma requires a personalized, multimodal approach.
Treatment options include surgery, radiotherapy, chemotherapy, targeted therapy, and immunotherapy.
Multidisciplinary management is key for favorable outcomes.

Conclusions:

Consider cutaneous angiosarcoma in scalp tumor differential diagnosis, especially with prior irradiation history.
Early detection, accurate diagnosis, and multidisciplinary care are crucial.
Wide surgical excision with clear margins and adjuvant radiotherapy improve prognosis.