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Related Experiment Video

Updated: Jun 9, 2026

Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils
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Chronic Periodontitis as a Risk Factor for Benign Prostatic Hyperplasia: A Cohort Study.

Mi Jung Kwon1, Ho Suk Kang2, Hyo Geun Choi3

  • 1Department of Pathology, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang 14068, Republic of Korea.

Journal of Clinical Medicine
|February 26, 2025
PubMed
Summary

Recurrent periodontitis episodes are linked to a higher risk of benign prostatic hyperplasia (BPH) in Korean men, especially those with low income or multiple health issues.

Keywords:
benign prostatic hyperplasiaepidemiologyperiodontitisrisk factors

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Area of Science:

  • Periodontology
  • Urology
  • Public Health

Background:

  • The relationship between periodontitis and benign prostatic hyperplasia (BPH) remains debated.
  • Understanding this association is crucial for public health initiatives and clinical practice.

Purpose of the Study:

  • To investigate the association between recurrent periodontitis episodes and the incidence of BPH in an adult Korean male population.
  • To explore potential socioeconomic and comorbidity-related variations in this association.

Main Methods:

  • A large-scale retrospective study using Korean National Health Insurance Service-Health Screening Cohort data.
  • Analysis of 79,497 matched cases and controls.
  • Conditional logistic regression models were employed to calculate odds ratios (ORs) and 95% confidence intervals (CIs), adjusting for confounders.

Main Results:

  • Participants with periodontitis (≥1 episode within 1 year) showed significantly higher odds of BPH (OR = 1.34).
  • The association was more pronounced in low-income individuals (OR = 1.43).
  • Increased frequency of periodontitis and higher comorbidity scores (CCI ≥ 2) correlated with progressively higher BPH odds.

Conclusions:

  • Recurrent periodontitis is associated with an increased occurrence of BPH.
  • Low income and multiple comorbidities amplify this risk.
  • Clinicians should consider periodontitis history when assessing BPH risk.