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Related Experiment Video

Updated: May 25, 2025

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Augmenting Cognitive Function in the Elderly with Mild Cognitive Impairment Using Probiotic Lacticaseibacillus

Su-Jin Jung1,2, Kyohee Cho3, Eun-Soo Jung1

  • 1Clinical Trial Center for Functional Foods, Jeonbuk National University Hospital, Jeonju 54907, Republic of Korea.

Nutrients
|February 26, 2025
PubMed
Summary

A low dose of MH-Pro, containing Lacticaseibacillus rhamnosus CBT-LR5 (LR5), significantly improved cognitive function and reduced amyloid-beta levels in older adults with suspected mild cognitive impairment (MCI). This suggests a potential gut-brain axis intervention.

Keywords:
Lacticaseibacillus rhamnosus CBT-LR5clinical trialcognitive functionmild cognitive impairment (MCI)probioticsskim milk

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Area of Science:

  • Neuroscience
  • Microbiology
  • Gerontology

Background:

  • Probiotics show potential for cognitive enhancement in mild cognitive impairment (MCI).
  • Efficacy of probiotics for cognitive function varies by strain and dosage.
  • Further clinical research is needed to confirm safety, efficacy, and mechanisms.

Purpose of the Study:

  • To assess the dosage, safety, and efficacy of MH-Pro (Lacticaseibacillus rhamnosus CBT-LR5 and skim milk) in older adults with suspected MCI.
  • To evaluate MH-Pro's impact on cognitive function and physiological changes over 12 weeks.

Main Methods:

  • A double-blind, parallel-group clinical trial involving 20 participants (mean age 68.9 years).
  • Participants were randomized into low-dose (1x10^10 CFU LR5 with 1622 mg skim milk) and high-dose (1x10^10 CFU LR5 with 4055 mg skim milk) groups.
  • Cognitive function, blood amyloid-beta levels, and fecal microbiota were analyzed over 12 weeks.

Main Results:

  • The low-dose group showed significant improvements in MOCA-K naming and delayed recall, and decreased blood amyloid-beta 40/42 levels.
  • Overall cognitive enhancement was significant in the low-dose group (p=0.003) and showed a trend in the high-dose group (p=0.06).
  • Fecal analysis indicated an increase in Lacticaseibacillus, suggesting gut-brain axis modulation.

Conclusions:

  • Foundational evidence supports MH-Pro (LR5 and skim milk) as a probiotic supplement for cognitive enhancement in the aging population.
  • The low-dose MH-Pro demonstrated significant cognitive benefits and physiological changes.
  • Further large-scale studies are warranted to validate these preliminary findings.