Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Post-traumatic Stress Disorder01:27

Post-traumatic Stress Disorder

806
Post-traumatic stress disorder (PTSD) is a psychiatric condition that arises following exposure to traumatic events such as natural disasters, forced displacement, or severe accidents. It significantly impairs individuals' ability to cope with daily activities and disrupts their emotional and psychological equilibrium.
Symptoms and Behavioral Manifestations
A spectrum of distressing symptoms characterizes PTSD. Recurrent flashbacks, where individuals involuntarily relive traumatic events,...
806
Traumatic Memory01:20

Traumatic Memory

667
Emotionally traumatic events often lead to memories that are exceptionally vivid and enduring, sometimes persisting with remarkable clarity throughout an individual's life. A classic example of this phenomenon is a person who survives a car accident. Even years later, they may recall every detail of the event with startling accuracy — the screeching of the tires, the jarring impact, and the acrid smell of burning rubber. Such vividness contrasts sharply with how an individual...
667
Role of Cerebellum and Prefrontal Cortex in Memory01:14

Role of Cerebellum and Prefrontal Cortex in Memory

1.4K
The cerebellum, while traditionally associated with motor control, also plays a crucial role in memory, particularly in procedural memory, which involves learning motor tasks that become automatic through repetition. For example, studies have shown that when the cerebellum is damaged, individuals or animals lose the ability to learn conditioned motor responses, such as the conditioned eye-blink response in classical conditioning experiments with rabbits. This study demonstrates the...
1.4K
Dissociative Disorders01:27

Dissociative Disorders

815
Dissociative disorders represent complex psychological conditions characterized by disruptions in consciousness, memory, identity, or perception. These disruptions cause individuals to experience a disconnection from their thoughts, emotions, and memories. The phenomenon is not merely an occasional lapse in attention but a profound alteration in mental functioning that can severely impact daily life.
Dissociative Fugue
A hallmark feature of dissociative disorders is the dissociative fugue...
815
Role of Amygdala in Memory01:16

Role of Amygdala in Memory

1.5K
The amygdala is a small, almond-shaped structure responsible for processing and storing memories, particularly those linked to emotions like fear and stress. It plays an essential role in the brain's response to emotionally significant events and often enhances memory formation by triggering stress hormone release. The amygdala is vital for encoding and retrieving memories associated with fear or stress, a process that is adaptive by helping organisms avoid dangerous situations.
One of the...
1.5K
Role of Hippocampus in Memory01:19

Role of Hippocampus in Memory

1.9K
The hippocampus, a critical brain structure, plays an essential role in memory processing, particularly in the formation and retrieval of memory. This small, seahorse-shaped region is located within the medial temporal lobe, with one hippocampus in each brain hemisphere. Experimental studies involving lesions in the hippocampi of rats have demonstrated significant impairments in tasks such as object recognition and maze navigation, indicating the hippocampus involvement in both recognition and...
1.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Mapping Practice-Based Signals of Generative AI in Psychiatric Care: Qualitative Study of Korean Psychiatrists' Experiences, Interpretations, and Implementation Priorities.

Journal of medical Internet research·2026
Same author

Delayed anterior mitral leaflet perforation after transcatheter aortic valve implantation with prosthesis-leaflet interaction.

European heart journal. Cardiovascular Imaging·2026
Same author

MASQ: A multiplex qPCR platform for quantitative alternative splicing analysis in clinical specimens.

Molecular therapy. Nucleic acids·2026
Same author

Bisoprolol vs. Carvedilol After Percutaneous Coronary Intervention in Acute Myocardial Infarction With Reduced Left Ventricular Ejection Fraction.

Circulation journal : official journal of the Japanese Circulation Society·2026
Same author

Complete revascularization timing in ST-segment elevation myocardial infarction and multivessel disease with heart failure: the OPTION-STEMI trial.

European heart journal·2026
Same author

CaliciBoost: Performance-driven evaluation of molecular representations for caco-2 permeability prediction.

Journal of cheminformatics·2025
Same journal

Relationships Between Eating Behaviors and Psychological Distress Among Female High School Students: A Social Network Analysis Perspective.

Psychiatry investigation·2026
Same journal

Psychological Factors Applicable to App Development for Overcoming Problematic Smartphone Use: A Structural Equation Modeling Approach.

Psychiatry investigation·2026
Same journal

How Is the Loneliness Affected by Family and Friend Support in Adolescents With Depressive Disorder: The Mediating Role of Coping Strategies.

Psychiatry investigation·2026
Same journal

Changes in Functional Brain Activity in School-Age Children 10 Years Later: A Resting State Functional Magnetic Resonance Imaging Study.

Psychiatry investigation·2026
Same journal

Paraben and Phthalate Exposure in Adolescents With Attention-Deficit/Hyperactivity Disorder: A Case-Control Study.

Psychiatry investigation·2026
Same journal

Autism Spectrum Disorder and Cardiovascular Risk: The Role of Frontal QRS-T Angle and Systemic Immune-Inflammation Index.

Psychiatry investigation·2026
See all related articles

Related Experiment Video

Updated: Mar 20, 2026

Developing Neuroimaging Phenotypes of the Default Mode Network in PTSD: Integrating the Resting State, Working Memory, and Structural Connectivity
10:43

Developing Neuroimaging Phenotypes of the Default Mode Network in PTSD: Integrating the Resting State, Working Memory, and Structural Connectivity

Published on: July 1, 2014

15.9K

Differences in Brain Structure and Functional Connectivity During Memory Processing in Posttraumatic Stress Disorder.

Shin-Eui Park1, Jae-Hee Chung2,3, Jong-Il Park2,3

  • 1Division of High-Tech Medical Devices, National Institute of Food and Drug Safety Evaluation, Ministry of Food and Drug Safety, Cheongju, Republic of Korea.

Psychiatry Investigation
|March 18, 2026
PubMed
Summary
This summary is machine-generated.

Posttraumatic stress disorder (PTSD) patients show altered brain structure and increased functional connectivity (FC) during memory tasks compared to healthy controls. These findings enhance understanding of PTSD neural mechanisms.

Keywords:
CerebellumMemory task.Posttraumatic stress disorderTask-based functional connectivityVoxel-based morphometry

More Related Videos

Biomarkers in an Animal Model for Revealing Neural, Hematologic, and Behavioral Correlates of PTSD
08:29

Biomarkers in an Animal Model for Revealing Neural, Hematologic, and Behavioral Correlates of PTSD

Published on: October 10, 2012

16.9K
Simultaneous Application of Transcranial Direct Current Stimulation during Virtual Reality Exposure
08:20

Simultaneous Application of Transcranial Direct Current Stimulation during Virtual Reality Exposure

Published on: January 18, 2021

4.6K

Related Experiment Videos

Last Updated: Mar 20, 2026

Developing Neuroimaging Phenotypes of the Default Mode Network in PTSD: Integrating the Resting State, Working Memory, and Structural Connectivity
10:43

Developing Neuroimaging Phenotypes of the Default Mode Network in PTSD: Integrating the Resting State, Working Memory, and Structural Connectivity

Published on: July 1, 2014

15.9K
Biomarkers in an Animal Model for Revealing Neural, Hematologic, and Behavioral Correlates of PTSD
08:29

Biomarkers in an Animal Model for Revealing Neural, Hematologic, and Behavioral Correlates of PTSD

Published on: October 10, 2012

16.9K
Simultaneous Application of Transcranial Direct Current Stimulation during Virtual Reality Exposure
08:20

Simultaneous Application of Transcranial Direct Current Stimulation during Virtual Reality Exposure

Published on: January 18, 2021

4.6K

Area of Science:

  • Neuroimaging
  • Psychiatry
  • Cognitive Neuroscience

Background:

  • Posttraumatic stress disorder (PTSD) is associated with significant alterations in brain structure and function.
  • Understanding the neural underpinnings of memory impairments in PTSD is crucial for developing targeted interventions.

Purpose of the Study:

  • To investigate the relationship between brain volume changes and memory task-based functional connectivity (FC) patterns in PTSD patients versus healthy controls (HCs).
  • To explore alterations in brain regions critical for memory encoding and retrieval in PTSD.

Main Methods:

  • Voxel-based morphometry (VBM) and task-based functional magnetic resonance imaging (fMRI) were utilized.
  • A memory task was employed to assess functional connectivity (FC) during encoding and retrieval phases.
  • Analysis focused on alterations in brain volume density and FC within and between memory-related brain regions.

Main Results:

  • PTSD patients exhibited increased gray matter (GM) volume in the right cerebellum (Cb).
  • While overall connectivity patterns were similar, PTSD patients showed higher and more widespread interregional FC compared to HCs.
  • Specific differences in FC were observed during memory encoding and retrieval, with PTSD patients showing altered connectivity in regions including the hippocampus, precentral gyrus, and orbitofrontal gyrus.
  • A negative correlation was found between PTSD symptom severity and right cerebellar GM volume.

Conclusions:

  • The study reveals distinct structural and connectivity alterations in the brains of individuals with PTSD.
  • Findings contribute to a deeper comprehension of the neural mechanisms underlying PTSD, particularly concerning memory processes.
  • These insights may inform future diagnostic and therapeutic strategies for PTSD.