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A Semi-Micro Extraction Spectrophotometric Determination of Iron Using 4-Nitrocatechol and Xylometazoline
Petya V Racheva1, Antoaneta D Saravanska1, Galya K Toncheva2
1Department of Chemical Sciences, Faculty of Pharmacy, Medical University of Plovdiv, 120 Buxton Bros Str., 4004 Plovdiv, Bulgaria.
Abstract:
A chromogenic solvent extraction system for Fe(III) based on 4-nitrocatechol (4NC) and xylometazoline hydrochloride (XMH) was investigated. The optimum conditions for extraction spectrophotometric determination of iron were found. Under these conditions, the formula of the extracted complex was (XMH+)3[Fe(4NC)3] and the apparent molar absorption coefficient at λmax = 464 nm was 1.9 × 105 dm3 mol-1 cm-1 (4-fold enrichment). To validate the aforementioned formula and gather information about the spin state of the central Fe(III) ion, a combined experimental-theoretical approach was employed. This approach entailed the experimental determination of the 4NC:Fe and XMH:Fe molar ratios and the optimization of potential color-bearing structures utilizing the B3LYP/6-311G computational chemistry method. The effect of foreign ions was thoroughly examined, and a sensitive, simple, and inexpensive analytical procedure was proposed, which was successfully applied for determining iron in pharmaceutical and industrial samples.
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