Atrial Fibrillation as an Independent Predictor of Myocardial Ischemia

Background and Objectives: Atrial fibrillation (AF) and coronary artery disease (CAD) are highly prevalent cardiovascular conditions. This study investigated the role of AF in myocardial ischemia, as assessed with myocardial perfusion imaging (MPI), in patients with suspected stable CAD. Materials and Methods: Our retrospective study included 259 individuals with a negative medical history of CAD who underwent 99mTc tetrofosmin MPI-single-photon emission computed tomography (SPECT)-for nonspecific symptoms to rule out stable CAD. Results: Of the enrolled patients, 90 MPIs were from patients with AF and 169 MPIs were from patients without AF. Semi-quantitative assessments of the extent and severity of perfusion abnormalities according to the summed stress score (SSS) and summed difference score (SDS) were conducted. It was found that patients with a history of AF, compared to patients without AF, were older (p < 0.001), of the male gender (p < 0.001), and had dyslipidemia (p = 0.019). History of AF was associated with increased SSS ≥ 4 (OR 5.12, p < 0.001) and SDS ≥ 2 (OR 2.66, p < 0.001). After adjustment for other risk factors, AF remained an independent predictor of myocardial ischemia on MPI-SPECT. Conclusions: In the current study, an association of AF with extensive perfusion defects in MPI-SPECT studies was found in patients with clinically suspected CAD independently of common cardiovascular risk factors.