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A Simplified Stepwise Approach to Echo Guidance during Percutaneous Mitral Valve Repair
08:31

A Simplified Stepwise Approach to Echo Guidance during Percutaneous Mitral Valve Repair

Published on: October 16, 2021

Mitral Transcatheter Edge-to-Edge Repair in Non-Surgical Candidates with Hypertrophic Obstructive Cardiomyopathy:

Emmanouil Chourdakis1,2, Kambis Mashayekhi1, Ulrich Schäfer3

  • 1Internal Medicine and Cardiology, Heart Center Lahr, 77933 Lahr, Germany.

Journal of Cardiovascular Development and Disease
|June 25, 2026
PubMed

Insights

Hypertrophic cardiomyopathy (HCM) can cause mitral regurgitation (MR) due to systolic anterior motion. Percutaneous edge-to-edge mitral valve repair offers a promising alternative treatment for symptomatic patients with hypertrophic obstructive cardiomyopathy (HOCM).

Area of Science:

  • Cardiology
  • Cardiac Surgery
  • Interventional Cardiology

Background:

  • Hypertrophic cardiomyopathy (HCM) is often underdiagnosed and undertreated, frequently leading to mitral regurgitation (MR).
  • Systolic anterior motion (SAM) of the anterior mitral leaflet is a primary cause of MR in HCM.
  • Current treatments for symptomatic hypertrophic obstructive cardiomyopathy (HOCM) include septal myectomy or transcoronary ablation of septal hypertrophy (TASH).

Purpose of the Study:

  • To provide a critical overview of percutaneous edge-to-edge mitral valve repair for HOCM.
  • To assess the current evidence regarding the efficacy and safety of this innovative technique.
  • To discuss future perspectives and unresolved issues in the treatment of HOCM-related MR.

Main Methods:

  • Review of current scientific literature and clinical evidence on percutaneous edge-to-edge mitral valve repair in HOCM patients.
  • Analysis of clinical outcomes, including symptom improvement and echocardiographic findings.
  • Discussion of the technique's role as an alternative to traditional surgical or interventional procedures.

Main Results:

  • Percutaneous edge-to-edge mitral valve repair shows promising results in improving clinical symptoms for HOCM patients.
  • Echocardiographic findings suggest significant reduction in mitral regurgitation after the procedure.
  • The technique represents a viable, less invasive alternative for selected patients.

Conclusions:

  • Percutaneous edge-to-edge mitral valve repair is an emerging and effective therapeutic option for HOCM with significant MR.
  • Further research is needed to fully establish its long-term efficacy and optimal patient selection criteria.
  • This minimally invasive approach holds potential to improve quality of life for patients with complex cardiac conditions.

Keywords:
M-TEERTASHhypertrophic obstructive cardiomyopathymitral regurgitation

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