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Bioremediation is the use of prokaryotes, fungi, or plants to remove pollutants from the environment. This process has been used to remove harmful toxins in groundwater as a byproduct of agricultural run-off and also to clean up oil spills.
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Primary Production01:06

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High-Throughput Metabolic Profiling for Model Refinements of Microalgae
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Mixotrophy in Marine Microalgae to Enhance Their Bioactivity.

Gabriella Licata1, Christian Galasso2, Fortunato Palma Esposito3

  • 1Department of Biological, Chemical and Pharmaceutical Sciences and Technologies (STEBICEF), University of Palermo, 90128 Palermo, Italy.

Microorganisms
|February 26, 2025
PubMed
Summary
This summary is machine-generated.

Mixotrophic cultivation boosts microalgal biomass and bioactive compound production. This method enhances algae

Keywords:
Chlorella sp.MS-HPLCNannochloropsis granulataPhaeodactylum tricornutumantibacterial activityanticancer activitybiological activitycytotoxicitymicroalgaephotoheterotrophy

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Area of Science:

  • Biotechnology and Sustainable Resources
  • Microalgal Cultivation and Applications
  • Climate Change Mitigation

Background:

  • Photosynthetic microorganisms, like microalgae, are key for carbon dioxide fixation and producing valuable biomolecules.
  • Mixotrophic growth, combining light with organic and inorganic carbon, enhances microalgal biomass and metabolic diversity.
  • Microalgae are crucial for climate mitigation and sustainable biotechnological applications.

Purpose of the Study:

  • To evaluate microalgal species (Nannochloropsis granulata, Phaeodactylum tricornutum, Chlorella sp.) under phototrophic and mixotrophic cultivation.
  • To assess the impact of mixotrophy on biomass production and bioactive compound generation.
  • To identify microalgal strains with significant antiproliferative and antibacterial activities.

Main Methods:

  • Cultivation of Nannochloropsis granulata, Phaeodactylum tricornutum, and Chlorella sp. under phototrophic and mixotrophic conditions.
  • Biomass yield assessment and measurement of bioactive compound production.
  • In vitro bioactivity assays, including antiproliferative and antibacterial testing.
  • Metabolomics analysis to identify bioactive compounds.

Main Results:

  • Mixotrophic cultivation significantly increased biomass production in all tested microalgal species.
  • Phaeodactylum tricornutum demonstrated potent antiproliferative activity against human melanoma cells and antibacterial effects against Staphylococcus aureus.
  • Chlorella sp. also exhibited antibacterial activity against Staphylococcus aureus.
  • Metabolomics analysis provided insights into compounds responsible for observed bioactivities.

Conclusions:

  • Mixotrophic cultivation is a valuable strategy for enhancing microalgal productivity and bioactivity.
  • Phaeodactylum tricornutum and Chlorella sp. show significant potential for pharmaceutical and biotechnological applications.
  • Microalgae are versatile organisms for sustainable development and climate change mitigation.