Exploring E-Vape Aerosol Penetration into Paranasal Sinuses: Insights from Patient-Specific Models

Area of Science:

• Otorhinolaryngology
• Drug Delivery Systems
• Aerosol Science

Background:

• Sinusitis significantly impairs quality of life, necessitating effective drug delivery to paranasal sinuses.
• Conventional methods like nasal sprays struggle to penetrate sinus ostia.
• This study explores e-vape aerosols as a potential solution for direct sinus drug delivery.

Purpose of the Study:

• To assess the efficacy of e-vape-generated aerosols in entering and filling paranasal sinus cavities.
• To compare e-vape aerosol penetration with traditional drug delivery devices.
• To investigate the mechanisms and optimal conditions for aerosol sinus entry.

Main Methods:

• E-vape generated aerosols of vegetable glycerin (VG) and propylene glycol (PG) were used.
• Patient-specific transparent nose-sinus models, including post-surgery, evaluated aerosol entry.
• Unidirectional and bidirectional airflow conditions were tested, with particle size analysis.

Main Results:

• E-vape aerosols effectively entered paranasal sinuses under specific conditions.
• Mean particle size ranged from 2.895-3.359 μm (median 2.963 μm).
• Aerosol entry speed correlated with ostia size; optimal filling occurred at 2 L/min flow rate, enhanced by pressure gradients and airflow dynamics.

Conclusions:

• E-vape generated aerosols demonstrate potential as a vehicle for direct paranasal sinus drug delivery.
• This method offers improved penetration compared to traditional devices.
• The findings suggest a promising avenue for enhancing sinusitis treatment outcomes.