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Updated: May 25, 2025

Author Spotlight: Advancements in Molecular Biomarker Testing for Non-Squamous Non-Small Cell Lung Cancer
07:59

Author Spotlight: Advancements in Molecular Biomarker Testing for Non-Squamous Non-Small Cell Lung Cancer

Published on: September 8, 2023

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Emerging Immunotherapies for Advanced Non-Small-Cell Lung Cancer

Emily Wolf1, Guilherme Sacchi de Camargo Correia1, Shenduo Li1

  • 1Division of Hematology and Medical Oncology, Mayo Clinic, 4500 San Pablo Rd, Jacksonville, FL 32224, USA.

Vaccines
|February 26, 2025
PubMed

Insights

Immune checkpoint inhibitors (ICIs) offer new hope for advanced non-small-cell lung cancer (NSCLC) patients. This review details current ICIs and emerging immunotherapies to overcome treatment resistance.

Area of Science:

  • Oncology
  • Immunology

Background:

  • Lung cancer is a leading global cause of cancer mortality.
  • Non-small-cell lung cancer (NSCLC) frequently presents at advanced stages.
  • Immune checkpoint inhibitors (ICIs) have revolutionized NSCLC treatment.

Purpose of the Study:

  • To review currently available ICIs for advanced NSCLC.
  • To describe emerging immunotherapies based on recent clinical trial data.

Main Methods:

  • Literature review of currently available ICIs for advanced NSCLC.
  • Summary of emerging immunotherapies from Phase I/II clinical trials.

Main Results:

  • ICIs targeting PD-L1, PD-1, and CTLA-4 have transformed advanced NSCLC therapy.
  • A subset of patients achieves durable responses, but most experience disease progression.
  • New drugs targeting novel pathways are under investigation to improve efficacy and overcome resistance.

Conclusions:

  • ICIs represent a significant advancement in treating advanced NSCLC.
  • Further research into novel immunotherapies is crucial to improve outcomes and address resistance patterns in NSCLC.
Keywords:
antibody–drug conjugatebispecific antibodiescancer vaccinescellular therapygut microbiomeimmune checkpoint inhibitorsimmunotherapymonoclonal antibodiesnon-small-cell lung cancertumor-infiltrating lymphocytes

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