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Vaccinations01:51

Vaccinations

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Overview
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Updated: May 25, 2025

Author Spotlight: Development of a Smartphone-Enhanced Paper-Based Device for Rapid Dengue NS1 Detection
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Dengue Vaccination: A Practical Guide for Clinicians.

Kay Choong See1

  • 1Division of Respiratory and Critical Care Medicine, Department of Medicine, National University Hospital, Singapore 119228, Singapore.

Vaccines
|February 26, 2025
PubMed
Summary
This summary is machine-generated.

Dengue vaccines offer protection but require careful use. Vaccination is recommended for those with prior dengue infection to prevent antibody-dependent enhancement (ADE), especially in endemic areas.

Keywords:
Aedesantibody-dependent enhancementflavivirusserogrouptravel medicinevector borne diseases

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Area of Science:

  • * Infectious Diseases
  • * Vaccinology
  • * Global Health

Background:

  • * Dengue fever presents a significant and escalating global health threat, characterized by increasing incidence and mortality rates.
  • * Urbanization and climate change are key drivers exacerbating the spread and impact of dengue.
  • * Effective prevention strategies, including vector control and vaccination, are crucial to mitigate the disease's substantial burden.

Purpose of the Study:

  • * To provide clinicians with a practical guide for the appropriate administration of dengue vaccines.
  • * To outline strategies for optimizing dengue vaccination in at-risk populations, including those in endemic regions and travelers.
  • * To address the safe and effective use of live-attenuated tetravalent dengue vaccines.

Main Methods:

  • * This narrative review synthesizes current clinical trial data and expert recommendations on dengue vaccine administration.
  • * It examines the efficacy and safety profiles of available dengue vaccines, such as Dengvaxia®, Qdenga®, and Butantan-DV.
  • * The review discusses strategies for risk mitigation, including the role of prior infection confirmation and point-of-care diagnostics.

Main Results:

  • * Live-attenuated tetravalent dengue vaccines demonstrate efficacy but necessitate careful administration due to the potential for antibody-dependent enhancement (ADE).
  • * Vaccination is primarily recommended for individuals with a documented history of dengue infection to minimize ADE risk.
  • * Co-administration with other vaccines is safe and immunogenic; however, live-attenuated vaccines are contraindicated in immunocompromised individuals and pregnant women.

Conclusions:

  • * Optimizing dengue vaccination requires enhanced clinician awareness, improved diagnostic capabilities, and prioritization of high-risk groups.
  • * Accessible point-of-care rapid testing is vital for identifying individuals eligible for vaccination and mitigating ADE risks.
  • * Integrated prevention programs incorporating vaccination are essential for reducing the global burden of dengue.