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Pulmonary arteriovenous malformation causing lung sequestration and media infarction: a case report
Raffaella Griffo1, Laura V Klotz1,2, Lena Brendel1
1Thoraxklinik, Department of Thoracic Surgery, Heidelberg University Hospital, Heidelberg, Germany.
Frontiers in Medicine
|February 26, 2025
Summary
Pulmonary arteriovenous malformations (PAVMs) are rare lung vascular issues. Early, multidisciplinary care is crucial for managing complex PAVMs and preventing severe complications, even after treatment.
Area of Science:
- Cardiology
- Pulmonology
- Vascular Surgery
Background:
- Pulmonary arteriovenous malformations (PAVMs) are uncommon lung vascular anomalies characterized by direct connections between pulmonary arteries and veins.
- This bypasses the pulmonary capillary system, impairing blood oxygenation and posing risks such as paradoxical embolism.
Observation:
- A complex PAVM case is presented, notably associated with a persistent foramen ovale.
- The initial presentation was a stroke, a critical neurological symptom linked to potential right-to-left shunting.
Findings:
- Despite prompt, multidisciplinary intervention for the PAVM, a severe, potentially fatal pulmonary complication arose.
- This underscores the unpredictable nature of PAVMs and their associated conditions.
Implications:
- Early and comprehensive interdisciplinary management is paramount for patients with PAVMs.
- Continuous follow-up is essential to mitigate life-threatening outcomes and manage long-term risks associated with these complex vascular malformations.

