A Scoping Literature Review of Pancreatic Panniculitis

Pancreatic panniculitis (PP) is a rare cutaneous manifestation of pancreatic disease, often presenting as tender, erythematous, subcutaneous nodules, typically on the lower extremities. It can also affect the upper extremities, buttocks, and abdomen. PP is associated with conditions such as acute pancreatitis, pancreatic acinar cell carcinoma, and pancreatic adenocarcinoma. In some cases, PP occurs as part of pancreatitis, panniculitis, and polyarthritis (PPP) syndrome, a clinical trial that also involves aseptic polyarthritis. While the pathophysiology of PP is not fully understood, cutaneous findings often resolve as pancreatic enzyme levels normalize. This study aims to summarize and characterize the demographics, distribution, morphology, symptoms, etiology, management, and outcomes of PP.