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Comprehensive Endovascular and Open Surgical Management of Cerebral Arteriovenous Malformations
Published on: October 20, 2017
Onyx Liquid Embolic Agent: Basic Knowledge for Its Use in Interventional Neuroradiology.
Takao Kojima1, Takuya Maeda1, Yuhei Ito1
1Department of Neurosurgery, Fukushima Medical University, Fukushima, Fukushima, Japan.
Onyx, a liquid embolic agent made of ethylene vinyl alcohol (EVOH) in dimethyl sulfoxide (DMSO), offers controlled delivery for treating brain vascular malformations. It provides durable occlusion of arteriovenous malformations and dural arteriovenous fistulas.
Area of Science:
- Interventional Neuroradiology
- Vascular Surgery
- Biomaterials Science
Background:
- Onyx is a non-adhesive liquid embolic agent.
- It is composed of ethylene vinyl alcohol (EVOH) copolymer dissolved in dimethyl sulfoxide (DMSO).
- It is designed for interventional neuroradiological procedures.
Purpose of the Study:
- To review the basic understanding of Onyx use in interventional neuroradiology.
- To highlight Onyx's role in treating intracranial vascular lesions.
- To discuss the mechanism of action and delivery of Onyx.
Main Methods:
- Review of Onyx formulation and properties.
- Description of Onyx delivery via microcatheters under fluoroscopic guidance.
- Explanation of the embolization process: DMSO diffusion and EVOH precipitation.
Main Results:
- Onyx allows controlled delivery and solidification within the target vessel.
- It provides durable occlusion of arteriovenous malformations and dural arteriovenous fistulas.
- The hydrophilic nature of Onyx facilitates smooth navigation and precise deposition.
Conclusions:
- Onyx liquid embolic agents represent a significant advancement in endovascular treatment.
- The agent enables precise treatment of intracranial vascular lesions.
- Onyx offers a reliable method for durable vascular occlusion.
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