Prognostic value of HALP score in predicting in-hospital mortality in patients with NSTEMI

Area of Science:

• Cardiology
• Clinical Medicine
• Biomarkers

Background:

• Non-ST segment myocardial infarction (NSTEMI) is a common cardiac emergency.
• Predictive markers for in-hospital mortality in NSTEMI patients are crucial for risk stratification.
• The HALP score, a composite biomarker, has not been extensively studied in the context of NSTEMI mortality.

Purpose of the Study:

• To investigate the association between the HALP score and in-hospital mortality in patients diagnosed with NSTEMI.
• To evaluate the predictive value of the HALP score for in-hospital mortality in this specific patient population.

Main Methods:

• A retrospective study involving 1648 NSTEMI patients.
• Patients were divided into two groups based on the median HALP score (3.87).
• Receiver Operating Characteristic (ROC) curve analysis and multivariate analysis were performed to assess mortality prediction.

Main Results:

• A low HALP score (<3.87) was associated with older age and a higher prevalence of comorbidities.
• A HALP score ≤ 2.62 demonstrated a sensitivity of 72.5% and specificity of 77.3% for predicting in-hospital mortality (AUC 0.809).
• The HALP score was independently associated with in-hospital mortality (OR: 0.504, 95% CI: 0.415-0.613, p < 0.001), along with age, diastolic blood pressure, Killip Class > 1, Syntax Score, creatinine, and LVEF.

Conclusions:

• The HALP score is independently associated with in-hospital mortality in NSTEMI patients.
• The HALP score shows potential as a valuable predictor of in-hospital mortality in this cohort.
• Further research may validate the HALP score for routine clinical use in NSTEMI management.