Related Experiment Video
Updated: Jan 9, 2026
Author Spotlight: Advancing the Analysis of Plasma Extracellular Vesicle Proteome for Cardiovascular Biomarker Studies
Published on: January 31, 2025
The Association of Plasma Osmolarity with No-Reflow in Patients with ST Elevation Myocardial Infarction: A
Şerif Hamideyin1, İnanç Artaç1
1Department of Cardiology, Kafkas University Faculty of Medicine, Kars, Turkey.
Insights
Higher plasma osmolarity is linked to no-reflow development in ST-segment elevation myocardial infarction (STEMI) patients undergoing primary percutaneous coronary intervention (pPCI). This suggests plasma osmolarity could predict no-reflow after pPCI.
Area of Science:
- Cardiology
- Biochemistry
Background:
- ST-segment elevation myocardial infarction (STEMI) is a critical condition requiring timely intervention.
- Primary percutaneous coronary intervention (pPCI) is the standard treatment for STEMI.
- No-reflow phenomenon is a complication that can occur after pPCI, impacting patient outcomes.
Purpose of the Study:
- To investigate the statistical association between plasma osmolarity and no-reflow development.
- To determine if plasma osmolarity is an independent predictor of no-reflow in STEMI patients treated with pPCI.
Main Methods:
- Retrospective analysis of 1294 STEMI patients who underwent pPCI.
- Plasma osmolarity calculated using the formula: 2 × sodium + 0.9 × glucose + 0.93 × urea × 0.5.
- Statistical analysis including multivariate logistic regression and receiver operating characteristic (ROC) curve analysis.
Main Results:
- The incidence of no-reflow was 21.7%.
- Mean plasma osmolarity was significantly higher in patients with no-reflow (300.6 mOsmol/L) compared to those without (292.8 mOsmol/L).
- Plasma osmolarity was independently associated with no-reflow (OR: 1.061, P < .001). An optimal cutoff of >290.2 mOsmol/L predicted no-reflow with 91.8% sensitivity.
Conclusions:
- This study establishes an independent relationship between higher plasma osmolarity and no-reflow development in STEMI patients post-pPCI.
- Plasma osmolarity may serve as a valuable predictive marker for no-reflow in this patient population.
Background:
In this study, we sought to examine the statistical association of plasma osmolarity with noreflow development in patients with ST-segment elevation myocardial infarction (STEMI) who were treated with primary percutaneous coronary intervention (pPCI).
Methods:
In this retrospective study, we included data from 1294 consecutive STEMI patients who have undergone pPCI. For each patient, we measured the plasma osmolarity using the following equation: 2 × sodium+0.9 glucose+0.93 × urea × 0.5.
Results:
Occurrence of angiographic no-reflow was 21.7% (n=281) in the study. The mean plasma osmolarity level was significantly higher in patients with no-reflow compared to those without no-reflow (300.6 ± 9.4 mOsmol/L versus 292.8 ± 10.5 mOsmol/L, P < .001, respectively). In multivariate logistic regression analysis, plasma osmolarity was found to be independently related to no-reflow development (odds ratio: 1.061; 95% CI, 1.045-1.076; P < .001). According to the receiver operating characteristic curve analysis, a plasma osmolarity level greater than 290.2 mOsmol/L was identified as the optimal value for predicting the occurrence of no-reflow. This cutoff demonstrated a sensitivity of 91.8% and a specificity of 45.8%.
Conclusion:
This is the first study to establish an independent relationship between higher plasma osmolarity and the development of no-reflow in patients with STEMI who have undergone pPCI. This finding suggests that plasma osmolarity may be a useful marker for the prediction of no-reflow in STEMI patients who have undergone pPCI.
More Related Videos
10:03Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty
Published on: January 28, 2020
18:11A Research Method For Detecting Transient Myocardial Ischemia In Patients With Suspected Acute Coronary Syndrome Using Continuous ST-segment Analysis
Published on: December 28, 2012
