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Updated: May 25, 2025

Author Spotlight: Exploring the Role of FAM83A in Cervical Cancer
Published on: February 9, 2024
Prognostic model for cervical cancer based on apoptosis-related genes
Lin Zhang1, Shunjie Zheng1, Pan Chen1
1Department of Gynecology, Affiliated Jinhua Hospital, Zhejiang University School of Medicine, Jinhua Maternal and Child Health Care Hospital, Jinhua City, P.R. China.
None:
This study attempts to develop a novel apoptosis-related predictive model for cervical cancer. Differentially expressed apoptosis-related genes were identified using TCGA, GEO, and MSigDB databases. A 13-gene prognostic model was constructed using multiple regression analyses. The low-risk group exhibited low tumor purity and high ESTIMATE and immune scores. Most of the immune checkpoints in the low-risk group were expressed at higher levels than those in the high-risk group. The low-risk group also had relatively more infiltrating immune cells. An independent prognostic model pertaining to cell apoptosis has been built by this work, which performs well in prediction.
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