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The role of different physical exercises as an anti-aging factor in different stem cells

Jia Xu1, Zhe Song2

  • 1College of Physical Education, North-West Normal University, Lanzhou, 730070, China.

Biogerontology
|February 26, 2025
PubMed

Insights

Physical exercise impacts cellular aging by affecting stem cells (SCs). Regular activity may slow senescence and improve SC function, offering a novel anti-aging strategy.

Area of Science:

  • Gerontology and Regenerative Medicine
  • Cellular Biology and Aging Research

Background:

  • Cellular senescence is a hallmark of aging, impacting stem cell (SC) function and renewal capacity.
  • Aging adversely affects SCs, diminishing their differentiation and self-renewal potential.
  • Physical exercise is linked to numerous health benefits and reduced risk of age-associated diseases.

Purpose of the Study:

  • To investigate the aging process in various stem cell (SC) types.
  • To explore the impact of physical activity on SC aging.
  • To discuss the role of sports and exercise as anti-aging interventions targeting SCs.

Main Methods:

  • Review of existing research on cellular senescence and SC aging.
  • Analysis of studies on the effects of physical exercise on SCs.
  • Examination of the impact of different sports on aged SCs and their niches.

Main Results:

  • Aging impairs the differentiation and renewal capabilities of stem cells (SCs).
  • Physical exercise positively influences various SC types, including mesenchymal, hematopoietic, neuronal, and muscular SCs.
  • Exercise-induced changes in the SC niche may affect the quantity and function of adult SCs.

Conclusions:

  • Physical activity can modulate the aging process in stem cells (SCs).
  • Exercise demonstrates potential as an anti-aging strategy by improving SC function and resilience.
  • Understanding the interplay between exercise and SC aging could lead to new therapeutic approaches.
Keywords:
AgingHematopoietic stem cellsHormesisMesenchymal stem cellsMuscular stem cellsPhysical exercisesStem cell

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