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Gut microbiota-derived metabolites: Potential targets for cardiorenal syndrome

Yuchen Lai1, Yujie Zhu2, Xihui Zhang3

  • 1School of Medicine, Wuhan University of Science and Technology, Wuhan 430065, China.

Pharmacological Research
|February 26, 2025
PubMed

Insights

Cardiorenal syndrome (CRS) involves simultaneous heart and kidney damage. Gut microbiota metabolites significantly impact CRS, offering new therapeutic targets for improved patient outcomes.

Area of Science:

  • Microbiology
  • Cardiology
  • Nephrology

Background:

  • Cardiorenal syndrome (CRS) is characterized by simultaneous heart and kidney damage, imposing a significant global health burden.
  • Emerging research highlights the role of host microbiota metabolism in triggering cardiac and renal injury, offering novel insights into cardiovascular risk.

Purpose of the Study:

  • To comprehensively review current research on gut microbiota-derived metabolites in the context of cardiorenal syndrome (CRS).
  • To elucidate the involvement of these metabolites in CRS pathophysiology and explore innovative therapeutic strategies.

Main Methods:

  • Literature review of bench-to-bedside studies focusing on gut microbiota-derived metabolites and CRS.
  • Analysis of the impact of metabolites on various pathophysiological pathways involved in CRS.

Main Results:

  • Gut microbiota metabolites are implicated in lipid/cholesterol disorders, coagulation issues, oxidative stress, and endothelial dysfunction in CRS.
  • These metabolites also contribute to inflammation, mitochondrial damage, energy metabolism disruption, vascular calcification, and renal fibrosis.
  • Emerging therapies targeting these metabolites show promise for innovative CRS treatment.

Conclusions:

  • Gut microbiota-derived metabolites play a crucial role in the complex pathophysiology of cardiorenal syndrome.
  • Targeting gut microbiota metabolism presents a promising avenue for novel therapeutic interventions to improve CRS patient prognosis and quality of life.
Keywords:
Cardiorenal syndromeGut microbiota-derived metabolitesHeart failureRenal insufficiency

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