Related Experiment Video

Updated: May 25, 2025

Exogenous Administration of Microsomes-associated Alpha-synuclein Aggregates to Primary Neurons As a Powerful Cell Model of Fibrils Formation
09:16

Exogenous Administration of Microsomes-associated Alpha-synuclein Aggregates to Primary Neurons As a Powerful Cell Model of Fibrils Formation

Published on: June 26, 2018

7.5K

Balancing act: lipid-to-protein ratios steer the aggregation fate of α-synuclein

Christian Blum1, Mireille M A E Claessens1

  • 1Nanobiophysics, Faculty of Science and Technology, MESA+ Institute for Nanotechnology and Technical Medical Centre, University of Twente, the Netherlands.

Trends in Biochemical Sciences
|February 26, 2025
PubMed

Keywords:
amyloidlipid membranesprotein aggregationprotein–membrane interactionsvesiclesα-synuclein (αSyn)

More Related Videos

Evaluation of the Impact of Protein Aggregation on Cellular Oxidative Stress in Yeast11:04

Evaluation of the Impact of Protein Aggregation on Cellular Oxidative Stress in Yeast

Published on: June 23, 2018

7.2K
Interactions with and Membrane Permeabilization of Brain Mitochondria by Amyloid Fibrils00:15

Interactions with and Membrane Permeabilization of Brain Mitochondria by Amyloid Fibrils

Published on: September 28, 2019

5.9K

Related Concept Videos

Amyloid Fibrils03:03

Amyloid Fibrils

Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
Amyloid deposits were observed as early as 1639 in the liver and the spleen.   In 1854, Rudolph Virchow performed iodine staining,...
9.2K