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Related Concept Videos

Extracorporeal Removal of Drugs: Continuous Renal Replacement Therapy01:26

Extracorporeal Removal of Drugs: Continuous Renal Replacement Therapy

Continuous Renal Replacement Therapy (CRRT) is an essential intervention for patients experiencing severe kidney dysfunction. This therapy offers a continuous mechanism for removing fluids and toxins from the bloodstream, leveraging the patient’s blood pressure to facilitate filtration through a specialized filter. This method contrasts with intermittent dialysis, providing a gentler and more consistent removal of waste products and excess fluid, which is particularly beneficial in critically...
Continuous Renal Replacement Therapy01:30

Continuous Renal Replacement Therapy

Continuous Renal Replacement Therapy, also known as CRRT, is a procedural treatment for acute kidney injury (AKI) that gradually removes uremic toxins and fluids while maintaining acid-base balance and stabilizing electrolytes. It is particularly useful for hemodynamically unstable patients. Unlike intermittent hemodialysis, which is faster, CRRT provides a gentler approach over 24 hours, closely mimicking the function of natural kidneys. However, CRRT is not ideal for patients with...
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Kidney Transplant I: Introduction

A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
Acute Kidney Injury V: Interprofessional Care01:20

Acute Kidney Injury V: Interprofessional Care

Acute Kidney Injury (AKI) requires a collaborative healthcare approach to restore renal function and prevent complications. Essential management strategies involve monitoring fluid and electrolyte balance, adjusting medications, initiating dialysis when necessary, and providing nutritional support.Fluid and Electrolyte ManagementFluid Monitoring: Regularly monitoring body weight, central venous pressure, and urine output helps detect fluid imbalances early. Patient intake and output are...
Chronic Kidney Disease I: Introduction01:25

Chronic Kidney Disease I: Introduction

Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...
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Chronic Kidney Disease III: Interprofessional Care

Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...

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Related Experiment Video

Updated: May 27, 2026

A Microfluidic-based Electrochemical Biochip for Label-free DNA Hybridization Analysis
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Microfluidic biosensors: revolutionizing detection in DNA analysis, cellular analysis, and pathogen detection.

Reza Didarian1, Mehdi Tayybi Azar2

  • 1Department of Biomedical Engineering, Ankara Yıldırım Beyazıt University, Ankara, Turkey. didarian.reza@gmail.com.

Biomedical Microdevices
|February 26, 2025
PubMed
Summary

Microfluidic biochips offer precise microscale fluid and bioparticle manipulation for advanced biological detection. This technology provides miniaturized, sensitive, and portable solutions for diverse applications, from medical diagnostics to environmental monitoring.

Keywords:
Biological DetectionCell AnalysisDNA AnalysisLab-on-a-chipMicrofluidicsPathogen Detection

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Area of Science:

  • Biotechnology
  • Analytical Chemistry
  • Microfluidics

Background:

  • Microfluidic chips enable precise manipulation of fluids and bioparticles at the microscale.
  • They offer significant advantages in detection applications, including miniaturization, enhanced sensitivity, and multiplexing capabilities.

Purpose of the Study:

  • To provide an overview of microfluidic biochip development for biological detection.
  • To discuss the diverse applications of microfluidic technology in various scientific fields.

Main Methods:

  • Review of microfluidic chip types (Lab-on-a-Chip, droplet-based, paper-based, electrochemical, optical, magnetic).
  • Analysis of applications in DNA analysis, immunoassays, chemical sensing, cell-based assays, medical diagnostics, and environmental monitoring.

Main Results:

  • Microfluidic chips replicate laboratory functions on a miniature scale, offering time and cost savings.
  • The technology supports portability and field-use capabilities for biological analysis.
  • Key applications include genetic and proteomic analysis, cell culture, biosensors, pathogen detection, and point-of-care diagnostics.

Conclusions:

  • Microfluidic biochips are pivotal in advancing chemical and biological analysis.
  • Their versatility and efficiency make them indispensable tools for modern scientific research and diagnostics.