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CD301b+ dendritic cell-derived IL-2 dictates CD4+ T helper cell differentiation

Naoya Tatsumi1,2, Jihad El-Fenej1,2, Alejandro Davila-Pagan1,2

  • 1Center for Immunity and Inflammation, Rutgers New Jersey Medical School, Newark, NJ, USA.

Nature Communications
|February 26, 2025
PubMed
Summary

CD301b+ dendritic cells (DCs) drive T helper 2 (Th2) cell differentiation by rapidly inducing IL-2 receptor signaling in CD4+ T cells. This DC-intrinsic CD40-IL-2 axis is critical for Th2 cell fate decisions.

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